摘要
目的比较TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效及毒副反应。方法 45例Ⅱb-Ⅳb期鼻咽癌患者随机分为TPF组(治疗组)、PF组(对照组),两组均行2周期诱导化疗,诱导化疗结束后一周开始同期放疗,期间观察毒副反应,同期放化疗结束后12周评价近期疗效。结果两组主要毒副反应均为血液学毒性及消化系统反应,治疗组CR率为85.7%、PR为14.3%,有效率为100%。对照组CR率为54.2%、PR为41.7%,总有效率95.9%,两组之间近期疗效有统计学差别。结论 TPF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌近期疗效优于PF方案诱导化疗联合同期放化疗。
Aim To investigate TPF,PF induction chemotherapy followed by cocurrent chemoradiotheapy for local advanced nasopharyngeal carcinoma.Methods Forty-seven patients with disease stageⅡb-Ⅳb were treated with either TPF group or PF group,Two groups were given 2 cycles induction chemotherapy,then two groups accepted cocurrent chemotherapy and the side effects observed,12 weeks after chemoradiotherapy evaluated the short-term effect of cure strategy.Results The main side effects were hematologic toxcity and digestive system toxicity of two groups.CR,PR were 85.7%and 14.3%respectively in TPF group.The overall response rate was 100%.CR,PR were 54.2% and 41.7% respectively in PF group.The overall response rate was 95.9%.There were significant differences between the two groups.Conclusion The TPF induction chemotherapy combined chemoradiotherapy treatment of local advanced nasopharyngeal carcinoma is more effective than the PF induction chemotherapy combined chemoradiotherapy in short-term effects.
出处
《安徽医药》
CAS
2011年第10期1291-1293,共3页
Anhui Medical and Pharmaceutical Journal
关键词
鼻咽癌
化学疗法
放射疗法
多西他赛
顺铂
氟尿嘧啶
nasopharyngeal carcinoma
chemotherapy
radiotherapy
docetaxel
cisplatin
5-FU
