摘要
目的探讨马来酸桂哌齐特(CM)治疗急性脑梗死的临床疗效及对血清中白介素-1β(IL-1β)、白介素-6(IL-6)含量的影响。方法选择2009年10月至2010年10月该院急性脑梗死患者82例,随机分为治疗组42例和对照组40例。治疗组在常规治疗基础上予CM注射液,对照组用盐酸丁咯地尔注射液。在治疗前及治疗后第2、7、14天记录两组患者神经功能积分值,并用ELISA测定血清IL-1βI、L-6含量。结果治疗组第2、7、14天血清IL-1βI、L-6水平较相同时间点的对照组明显降低且明显低于治疗前(P<0.01);两组治疗后第7、14天的卒中量表(NIHSS)评分均较治疗前有显著改善(P<0.05),但两组患者在治疗后第2、7、14天的NIHSS评分差异无统计学意义(P>0.05)。结论 CM治疗急性脑梗死疗效可靠且可降低血清IL-1βI、L-6对脑细胞的致炎作用。
Objective To study the effects of cinepazide maleate on serum IL-1β,IL-6 and neural function scoring of patients with acute cerebral infarction.Methods 82 patients with acute cerebral infarction were randomly divided into treatment group（n=42） and control group（n=40）.Patients in the treatment group were administered with cinepazide maleate while these in the control group were given buflomedil hydrochloride.The neural function scoring were evaluated and the levels of serum IL-1β,IL-6 were detected before treatment and 2,7,14 days after treatment.Results The serum IL-1β,IL-6 levels in treatment group were significantly reduced on 2,7,14 d after treatment when compared with these of control group（P0.01） and those before treatment（P0.01）.The NIHSS scores on 7,14 d in both groups were obviously improved than these before treatment（P0.05）,while no difference was found between the tow groups at each time point,and the therapeutic effect on 14 d in both groups was not significant（P0.05）.Conclusion The cinepazide maleate is effective as a treatment to acute cerebral infarction and can alleviate the inflammatory effects of serum IL-1β,IL-6 to brain cells.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第25期2532-2533,2536,共3页
Chongqing medicine
