摘要
目的评价美托洛尔联合稳心颗粒治疗风湿性心脏病换瓣术后频发室性期前收缩的临床疗效及安全性。方法将风湿性心脏病换瓣术后频发室性期前收缩患者68例,随机分为两组。两组患者均常规口服美托洛尔,治疗组加服稳心颗粒,每次9g,每日3次,2周为1个疗程。观察两组患者临床症状、24h动态心电图、华法林用量、凝血酶原时间(PT)及国际化标准比值(INR)变化。结果治疗1个疗程后,两组症状及室性期前收缩明显减少。治疗组临床疗效总有效率91.18%,明显高于对照组79.41%(P<0.05),24h室性期前收缩减少总有效率88.23%,明显高于对照组82.35%(P<0.05),且未见严重不良反应。两组治疗前后华法林用量、PT及INR无明显差异(P>0.05)。结论稳心颗粒联合美托洛尔治疗风湿性心脏病术后室性频发早搏疗效明显,优于单用美托洛尔,且对华法林抗凝治疗无明显影响。
Objective To observe the efficacy and safety of Wenxin granule combined with metoprolol for treatment of frequent ventricular premature contractions in patients（pts） with rheumatic heart disease after valve replacement surgery.Methods Sixty-eight pts with frequent ventricular premature contractions and rheumatic heart disease after valve replacement surgery were randomly divided into two groups：Control group treated by metoprolol and treatment group treated by Wenxin granule and metoprolol for 2 weeks.The therapeutic effect,24 h Holter electrocardiogram（ECG）,prothrombin time（PT） and the international normalised ratio（INR） were compared between 2 groups.Results The efficacy rate was 91.18% in treatment group,which was significantly higher than that in control group（79.41%,P0.05）.The effective rate of ventricular premature contractions was 88.23% in treatment group,which was significantly better than that in control group（82.35%,P0.05）.The dose of warfarin,PT,and INR had no difference significantly.There were no obvious adverse effects in both groups.Conclusion Wenxin granule combined with metoprolol was more effective than metoprolol,and it was safe for treatment of frequent ventricular premature contractions in pts with rheumatic heart disease after valve replacement surgery.Wenxin granule combined with metoprolol did not affect anticoagulation of warfarin.
出处
《中西医结合心脑血管病杂志》
2011年第9期1063-1064,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
稳心颗粒
美托洛尔
室性期前收缩
风湿性心脏病
Wenxin granule
metoprolol
ventricular premature contractions
rheumatic heart disease
