摘要
目的应用超声观察高泌乳素血症对女性精神分裂症患者乳腺的影响。方法应用高频超声对106例女性精神分裂症患者的乳腺进行检查。分析乳腺改变与患者症状、年龄、病程及血清泌乳素水平的关系。结果 106例女性精神分裂症患者中高泌乳素血症87例(占82%),其中60例伴有乳腺导管扩张(占69%);13例伴溢乳(占22%)。乳腺导管扩张程度与血清泌乳素水平有关(P<0.01),乳腺导管扩张程度与年龄及病程无明显相关(P>0.05)。结论高泌乳素血症可引起女性精神分裂症患者的乳腺导管扩张及溢乳,应引起临床重视,对患者乳腺的远期影响须追踪观察。
Objective To investigate the effects of hyperprolactinemia on the morphology of the breasts in female chronic schizophrenia patients using mammary ultrasonography.Methods One hundred and six female chronic schizophrenia patients were examined.The age of patients ranged from 18 to 59 years old.Mammary ultrasonography was used to observe breast glandular section thickness,breast duct width,and the blood flow of color Doppler imaging at baseline.The serum prolactin was also measured,defined as a level above the upper limit of normal（26.72 ng/mL for females）.Results Eighty-seven patients had hyperprolactinemia（82%）,thirteen（22%） were associated with nipple discharge;sixty showing duct ectasia（69%）;duct ectasta is positively related to the serum prolactin level（P0.01） and negatively to the age and period of the disease（P0.01）.Conclusion Hyperprolactinemia may result in duct ectasia and nipple discharge among the subjects,and can influence life quality of the patients,therefore doctors should pay more attention to hyperprolactinemia of female schizophrenia patients.Mammary ultrasonography can be used to evaluate breast structure changes and breast lesions in follow-up.
