摘要
目的观察新型5-羟色胺(5-HT3)受体拮抗剂托烷司琼预防老年患者行妇科腹腔镜术后恶心呕吐的临床效果。方法采用随机、安慰剂对照和双盲的研究方法,将90例择期行腹腔镜下妇科手术老年患者分成3组:托烷司琼5mg组(T组)、格拉司琼3mg组(G组)和0.9%氯化钠注射液对照组(S组),每组30例。麻醉诱导均采用咪达唑仑、舒芬太尼、罗库溴铵、丙泊酚,气管插管后接麻醉机行机械通气。麻醉维持采用持续泵注丙泊酚,间断静脉滴注罗库溴铵、舒芬太尼维持。术毕入麻醉复苏室(PACU),专人负责观察患者,记录术后恶心、呕吐程度评分。结果 T组和G组恶心呕吐发生率明显低于S组(P<0.05),而T组和G组2组之间则差异无统计学意义(P>0.05)。结论托烷司琼能够有效预防妇科腹腔镜手术老年患者恶心呕吐发生,并降低其严重程度。
Objective To observe the prophylactic antiemetic effect of tropisetron,the new 5-hydroxytryptamine3（5-HT3） antagonists in PONV elderly female patients undergoing gynecological laparoscopic surgery.Methods Ninty elderly female patients under general anesthesia were enrolled in this study.The patients were randomly assigned to one of three study groups： tropisetron 5 mg（T group）,granisetron 3 mg（G group） and saline 1 mL（S group）,30 cases in each group.Anesthesia was induced with midazolam,sulfentanyl,rocuronium,propofol,and maintained with propofol and rocuronium.Postoperation to PACU,a special anesthesiologist observing the patients,recording the degree of nausea and vomiting.Results The incidence of nausea and vomiting did not differ significantly between T group and G group（P0.05）,but the incidence of nausea and vomiting did differ significantly among S group and these two groups（P0.05）.Conclusion Tropisetron is effective for the prevention of postoperative nausea and vomiting in elderly female patients undergoing gynecological laparoscopic surgery.
基金
辽宁省高等学校科学研究项目(2008796)
关键词
腹腔镜检查
托烷司琼
手术后恶心呕吐
女性
老年
Laparoscopy
Tropisetron
Postoperative nausea and vomiting
Female
elderly
