摘要
目的探讨瓜子金提取物及其不同部位的抗炎、镇痛活性。方法采用醋酸扭体法进行镇痛实验,采用二甲苯致小鼠耳肿胀、醋酸致小鼠腹腔通透性增加、角叉菜胶致小鼠足趾肿胀实验进行抗炎实验,对瓜子金的甲醇提取物及其各个萃取部位进行镇痛和抗炎实验。结果瓜子金甲醇提取物及乙酸乙酯部位和正丁醇部位对醋酸所致小鼠扭体反应有较好的抑制作用,可以显著抑制二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致的小鼠足趾肿胀。结论 在相同剂量下,瓜子金的甲醇提取物显示出较好的镇痛活性,乙酸乙酯部位和正丁醇部位相对具有较好的抗炎活性。
Objective To evaluate the analgesic and anti-inflammatory effects of the methanol extract and its different fractions from Polygala japonica. Methods The methanol extract from Polygala japonica and its fractions （petroleum ether fraction, ethyl acetate fraction, n-butanol fraction and water residure fraction） were obtained by solvent partition of its total extract. Analgesic effect was observed by acetic acid-induced writhing response in mice, and anti-inflammatory effects were investigated on xylene-induced ear swelling in mice, acetic acid-induced peritoneal capillary permeability in mice, carrageenan-induced paw edema in mice. Results The methanol extract including ethyl acetate fraction and n-butanol fraction could inhibit twisting response of mice, and could reduce pedal swelling and aurical swelling obviously. Conclusion In the same dose, the methanol extract shows analgesic effect obviously, while anti-inflammatory activities might be mainly ascribable to ethyl acetate fraction and n-butanol fraction.
出处
《现代中药研究与实践》
CAS
2011年第5期40-42,共3页
Research and Practice on Chinese Medicines
基金
江苏省高校自然科学研究项目资助(10KJB360002)
高等学校博士学科点专项科研基金(20103237120011)
关键词
瓜子金
镇痛作用
抗炎作用
Polygalajaponica
analgesic effect
anti-inflammatory effect
