摘要
目的探讨吸烟对男性精浆一氧化氮、微量元素及精子三磷酸腺苷（ATp）水平的影响。方法124例男性不育患者根据有无吸烟分为不育非吸烟组和不育吸烟组，不育吸烟组又根据吸烟习惯和烟龄分为3组：A组日吸烟量〈10支，且烟龄〈5年；B组日吸烟量10—20支，且烟龄5～10年；C组日吸烟量〉20支，且烟龄〉10年。选择35例已生育正常健康男性为正常对照组。检测其精浆一氧化氮、微量元素及精子ATP的水平。结果不育吸烟组和不育非吸烟组较正常对照组精浆一氧化氮、铅和镉水平明显升高，锌、铜和精子ATP水平明显降低，差异均有统计学意义（P〈0．05），不育吸烟组较不育非吸烟组精浆一氧化氮、铅和镉水平明显升高，锌、铜和A，rP水平明显降低，差异均有统计学意义（P〈0．05）。C组精浆一氧化氮、铅和镉水平均显著高于A组和B组，锌、铜和精子ATP水平均显著低于A组和B组，差异有统计学意义（P〈0．05）。结论吸烟可以影响精浆一氧化氮、微量元素及精子ATP的水平，与不育密切相关。
Objective To explore the influence of cigarette smoking on seminal plasma nitric oxide, trace elements and ATP. Methods A total of 124 infertile men were divided into the smoking group and the non - smoking group, with the smoking group further divided into 3 subgroups according to daily smoking quantity and smoking duration （group A： 〈 10 ciga- rettes, 〈5 years; group B： 10 -20 cigarettes, 5 ~ 10 years; group C： 〉20 cigarettes, 〉 10 years） . Thirty -five procreated healthy men were enrolled as controls and seminal plasma nitric oxide, trace elements and ATP in all subjects were detec- ted. Results Seminal plasma nitric oxide, Pband Cd were significantly higher, while Zn, Cu, and ATP content were signifi- cantly lower, in the infertile smoking group and infertile non - smoking group than in the normal group （ P 〈 0.05 ） . Seminal plasma nitric oxide, Pb and Cd were significantly higher, while Zn, Cu, and ATP content were significantly lower, in the infer- tile smoking group than in the infertile non - smoking group （P 〈 0.05 ） . Seminal plasma nitric oxide, Pb and Cd were signifi- cantly higher, while Zn, Cu, and ATP content were significantly lower, in subgroup C than in subgroup A and B （P 〈 0. 05）. Conclusion Smoking is closely related to male infertility through increasing seminal plasma nitric oxide, Pb and Cd and decrea- sing Zn, Cu and ATP content, and thus the quality of semen.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第26期2976-2978,共3页
Chinese General Practice
关键词
吸烟
精液
一氧化氮
腺苷三磷酸
Smoking
Semen
Nitric oxide
Adenosine triphosphate
