摘要
目的考察不同浓度醋酸氯己定对引起急慢性咽炎的主要致病菌(乙型溶血型链球菌、变形菌、肺炎双球菌、金葡球菌)的体外抑菌作用。方法采用96孔板测定醋酸氯己定对几种菌的最小抑菌浓度值(MIC),打孔法测定不同浓度醋酸氯己定对引起急慢性咽炎的几种主要致病菌的体外抑菌作用。结果醋酸氯己定对乙型溶血型链球菌、变形菌、肺炎双球菌、金葡球菌均有明显的抑菌作用,且最小抑菌浓度分别7.81×10-3、0.0313、3.91×10-3和1.96×10-3mg/mL。结论醋酸氯己定对引起急慢性咽炎的乙型溶血性链球菌、变形菌、肺炎双球菌以及金葡球菌等几种病原菌均有较强的抗菌活性,可用于急慢性咽炎的辅助治疗。
Objective To evaluate the antibacterial activity of different concentrations of chlorhelxidine acatate against several pharyngitis pathogens. Methods MICs of chlorhelxidine acatate at different concentrations on against p-Streptococcus pyogens, Proteusbacillus vulgaris, Dneumococcus and Staphylococcus aureus were determined by 96- well plates method and the antibacterial activity were determined by driling method. Results Chlorhexidine acetate can inhibit or kill the four acute and chronic pharyngitis bacteria effectively and the MICs of chlorhexidine acetate on β-Streptococcus pyogens, Proteusbacillus vulgaris, Dneumococcus and Staphylococcus aureus Rosenbach was 7.81 ×10^-3, 0.0313, 3.91 ×10^-3 and 1.96×10^-3mg/mL respectively. Conclusion The activity of chlorhexidine acetate against β-Streptococcus pyogens, Proteusbacillus vulgaris, Dneumococcus and Staphylococcus aureus Rosenbach was strong. Chlorhexidine acetate can be used to treat acute and chronic pharyngitis.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第9期712-715,共4页
Chinese Journal of Antibiotics
关键词
醋酸氯己定
咽炎
病原菌
抑菌试验
Chlorhexidine acetate
Pharyngitis
Pathogenic bacterium
Antibacterial activity test
