摘要
目的分析儿童特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura,ITP）的临床表现及治疗情况,比较急、慢性ITP的不同点。方法对安徽医科大学第一附属医院2008年1月-2010年12月期间,住院的202例ITP病例临床资料进行回顾性分析。结果 202例ITP患儿,男106例（52.48%）,女96例（47.52%）,急性ITP 177例（87.62%）,慢性、难治性ITP 25例（12.38%）,6岁及以下患儿156例（77.23%）,6岁以上46例（22.77%）;有174例（86.14%）ITP患儿发病时血小板呈重度、极重度减少,但临床多为轻度出血（81.68%）;急性组单用激素治疗有效率89.66%,单用丙种球蛋白治疗有效率73.33%,两者联合治疗有效率为88.98%;慢性、难治性ITP激素联合丙种球蛋白治疗有效率54.55%。结论儿童ITP多见于6岁及以下,男女发病机会均等,该病临床发病急而症状轻。对急性ITP应用激素和（或）丙种球蛋白治疗可取得较好的疗效。
Objective To analyze the characteristics and therapy efficiency of children idiopathic thrombocytopenic purpura （ITP）, and compare the differences between acute and chronic ITP. Methods 202 cases of idiopathic thrombocytopenic purpura who were diagnosed and treated in the First Affiliated Hospital of Anhui Medical University from 2008 to 2010 were reviewed. Results Among 202 cases （106 male and 96 female）, acute ITP was 177 cases （87.62%）, chronic ITP （CITP） and refractory ITP （RITP） were 25 cases （ 12.38% ）. Most of acute ITP in children were less than 6 year old （77.23%）. 174 cases （86.14%） of ITP had severe thrombocytopenia and 81.68% of them showed mild bleeding. For acute ITP, the efficiency of different therapy had no significant difference in Pred group （89.66 % ）, IVIG group （73.33%） and combination group （88.98%）, respectively. But it was lower in combination group in chronic/refractory ITP （54.55 % ）. Conclusions Childhood ITP mostly occur at the age of 1 to 6 year, the incidence of ITP is equal between men and women, the majority of the children＇s ITP cases are acute course with mild bleeding and recover fast.
出处
《中华疾病控制杂志》
CAS
2011年第9期755-757,共3页
Chinese Journal of Disease Control & Prevention
关键词
紫癜
血小板减少性
特发性
儿童
疾病特征
Purpura, thrombocytopenic, idiopathic
Child
Disease attributes
