摘要
目的:分析组织工程人工食管不同代替材料的应用及相容性,探讨其在老年食管癌置入后的疗效,寻求永久性的人工植入材料。方法:以gene chip,protein chip,artificial neural network,gastrointestinal cancer,diagnosis"为英文检索词,"组织工程食管、人工食管,生物相容性,食管瘤,诊断"为中文检索词。由第一作者检索2000-01/2010-09PubMed数据及万方数据库,纳入与组织工程食管研究、人工食管置入后的生物相容性评价以及不同材料组织工程食管的实验分析相关的文献,排除重复性研究。保留中英文30篇文献进一步归纳总结。结果:目前人工食管主要的并发症有吻合口瘘、狭窄、坏死、反流等。未来人工食管的研究方向主要集中在人工食管的构建理念以及构建材料的选择上,主要有以下几种观点:①选择理想的材料并构建成合适的形状。②体外培养-移植体内-诱导食管再生。③研制一种可精确调控的可生物降解的生物型人工食管,直接将其植人机体内,并以此为支撑物,在体内最终诱导、再生出新生的食管。结论:组织工程食管的研究有朝着应用组织工程学方法构建与正常食管结构相类似的食管替代物,材料的选择从单一的生物惰性材料向可降解吸收的生物活性材料转变的多元化研究发展的趋势。
OBJECTIVE： To analyze the application and compatibility of different fungible material of artificial esophagus for tissue engineering, and explore the curative effect on esophageal carcinoma of old patients after implantation, in order to find nonvolatile artificial implant material. METHODS： Taking ＂gene chip, protein chip, artificial neural network, gastrointestinal cancer, diagnosis＂ in English and ＂tissue engineering esophagus, artificial esophagus, biocompatibility, esophageal carcinoma, diagnosis＂ in Chinese was utilized as search terms to retrieve PubMed database （2000-01/2010-09） and Wanfang database by the first author. Literatures related to tissue engineering esophageal research, evaluation of biocompatibility after artificial esophagus implantation and experimental analysis of different materials for tissue engineering esophagus were included. Duplicated articles were excluded. A total of 30 literatures were obtained for further summarization. RESULTS： At present, the main complications of artificial esophagus including anastomotic fistula, narrow, necrosis, contraflow. Future research directions of artificial esophagus are mainly on construction and the choice of material. The main views were as followed： ①Ideal materials were selected and their suitable shape was constructed. ②The materials were cultured in vitro, and transplanted in vivo, then esophageal regeneration was induced. ③A biodegradable biological artificial esophagus with accurate control was developed, and then transplanted into organism and served as supporter, finally induced in vivo so as to regenerate newborn esophagus. CONCLUSION： The research of tissue engineering esophagus toward the similar esophageal substitute with normal esophageal structure constructed by tissue engineering method, the choice of materials from a single biological inert materials to resorbable and degradable bioactive materials into a diversified research and development trends.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第16期2965-2968,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
