摘要
目的了解系统性红斑狼疮(SLE)患者外周血中D-二聚体的水平及其临床价值。方法用免疫比浊法测定50例SLE患者血浆D-二聚体水平,研究其与SLE的疾病活动及临床表现的关系。结果 (1)SLE患者血浆D-二聚体水平较正常组显著增高(P<0.001);(2)与D-二聚体水平正常组SLE患者相比,D-二聚体水平升高组SLE患者的SLEDAI积分明显升高(P<0.05),且D-二聚体水平与SLEDAI积分呈显著正相关(r=0.682,P<0.01);(3)抗心磷脂抗体阳性患者与抗心磷脂抗体阴性患者的血浆D-二聚体水平无显著差异(P>0.05),但继发抗磷脂综合征患者血浆D-二聚体水平高于无继发抗磷脂综合征的SLE患者(t=2.157,P=0.03);(4)狼疮肾炎患者血浆D-二聚体水平高于无狼疮肾炎患者(P<0.05)。结论 SLE患者检测血浆D-二聚体,有助于了解SLE疾病的活动性。
Objective To study the clinical significance of plasma D-dimer in patients with systemic lupus erythematosus（SLE）.Methods The levels of plasma D-dimer in 50 SLE patients were measured by immunoturbidimetry.Results（1）The levels of D-dimer in SLE patients were significantly higher than those in the controls（P0.001）.（2）Compared with SLE patients who have the normal levels of D-dimer,the SLE patients with high levels of D-dimer have a significantly higher SLEDAI scores（P0.05）,and the levels were showed a significant positive correlation with SLEDAI scores（r=0.682,P0.01）.（3）There was no significant difference on levels of D-dimer between the SLE patients with different levels of anticardiolipin antibodies（P0.05）,but the levels of plasma D-dimer in SLE with secondary anti-phospholipid antibody（APS） were obviously higher than that in SLE without secondary APS（t=2.157,P=0.03）.（4）The levels of plasma D-dimer in SLE with lupus nephritis（LN） were obviously higher than that in SLE without LN（P0.05）.Conclusion Levels of plasma D-dimer in SLE patients might be valuable for assessment of disease activity.
出处
《黑龙江医学》
2011年第8期561-563,共3页
Heilongjiang Medical Journal
