摘要
目的研究血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与原发性高血压(EH)合并缺血性脑卒中(IS)(EH+IS)的关系。方法检索1997年1月～2010年10月4个中国著名科技期刊全文数据库和Medline中收录的有关ACE基因I/D多态性与EH+IS的病例对照研究的文献,按纳入、排除标准选择文献,并采用RevMan 5.0软件进行Meta分析。结果共纳入12项病例对照研究,其中EH+IS患者1068例,EH患者1225例。Meta分析结果表明,EH人群携带D等位基因和DD基因型者发生IS的危险性分别明显高于I等位基因和非DD基因型者,合并OR分别为1.50(95%CI:1.33～1.70)和1.83(95%CI:1.32～2.55);而携带II基因型者发生IS危险性要低于非II基因型者,合并OR为0.63(95%CI:0.53～0.76)。结论 ACE基因I/D多态性与EH人群IS的发病有密切关系,D等位基因和DD基因型是IS的危险因素。
Objective To research the relationship between angiotension-converting enzyme （ACE） gene insertion/deletion（I/D） polymorphism and essential hypertension（EH） complicated with ischemic stroke（IS） （EH ＋ IS）. Methods The case-control studies of ACE gene I/D polymorphism and EH ＋ 1S in 4 famous Chinese technological periodical full-text database and Medline from January 1997 to October 2010 were searched. The literatures were selected by inclusion and exclusion criteria and were Meta-analyzed by RevMan 5.0 software. Results The 12 case-control studies were included, in which patients with EH ＋ IS were 1068 cases and patients with EH were 1225 cases. Meta-analysis results showed that the risk of occurrence of IS in the population of EH who carried D allele and DD genotype was significantly higher than who carried I allele and non-DD genotype respectively, and the pooled OR were 1.50 （95% CI： 1.33 - 1.70） and 1,. 83 （95% Cl： 1.32 - 2.55） respectively. The risk of occurrence of IS in the population of EH who carried II genotype was significantly lower than who carried non-II genotype, and the pooled OR was 0.63 （ 95% CI： 0. 53 - 0. 76 ）. Conclusions ACE gene I/D polymorphism is significantly associated with the occurrence of IS in the population of EH. D allele and DD genotype are risk factors of IS.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第4期244-247,共4页
Journal of Clinical Neurology
基金
国家自然科学基金资助项目(30671796)
