摘要
目的:比较顺铂或多西紫杉醇同期放化疗治疗局部晚期宫颈癌疗效。方法:38例IIb到IVa期患者随机分为每周顺铂同期放化疗组(22例)或多西紫杉醇同期放化疗组(16例)。顺铂30mg/m2或多西紫杉醇25mg/m2抗过敏预处理,每周放疗的第一天同步静脉滴注,连续6周;放疗方法:两组患者外照射放疗采用直线加速器盆腔大野DT 30Gy后中央挡铅改为盆腔四野加量照射至DT 50Gy,常规分割,180-200cGy/F,盆腔四野照射期间每周局部后装铱192照射一次,每次剂量6Gy,共6次,A点剂量达3600cGy。观察两组治疗效果和不良反应并进行比较。结果:两组患者总有效率82%vs 87%,临床获益率91%vs 94%,差异无统计学意义(P>0.05);两组随访1年无进展生存率(PFS)比较77%vs 81%,总生存率(OS)95%vs 100%,差异无统计学意义(P>0.05);但多西紫杉醇同期放化组较顺铂同期放化组治疗无论在血液系统不良反应和非血液系统不良反应方面都明显降低,统计学比较差异有显著性P<0.05。结论:多西紫杉醇同期放化疗可取得不亚于顺铂同期放化治疗的疗效,且多西紫杉醇不良反应明显降低。
Objective：To compare the effect of cisplatin and docetaxel concurrent chemotherapy and radiotherapy in local advanced cervical cancer.Methods： Totally 38 cases with stage IIb-IVa cervical cancer were randomized into two groups：cisplatin group（n=22） and docetaxel（n=16）.Both two groups underment the same irradiation,while cisplatin group was given cisplatin at a dose of 30mg/m2 every week once for 6 cycles and docetaxel group was given docetaxel at a dose of 25mg/m2/every week once for 6 cycles.Both groups received radiotherapy with 30 Gy first and were irradiated by the combination of external radiotherapy plus intracavitary irradiation.Results： The effective rate was 82% in cisplatin group and 87% in docetaxel group after radiotherapy（P0.05）.The clinical gain benefits rate was 91% in cisplatin group and 94% in docetaxel group after radiotherapy（P0.05）.The one year free-progress survival and overall survival was 77% vs 81% and 95% vs 100% in cisplatin gruop and docetaxel group（P0.05）.Howerever docetaxel group showed a significant lower hematologic or non-hematologic toxicity than cisplatin group（P0.05）.Conclusion： Docetaxel concurrent chemotherapy and radiotherapy can get the same effect with cisplatin concurrent chemotherapy and radiotherapy with the obvious lower side effect.
出处
《现代肿瘤医学》
CAS
2011年第9期1827-1830,共4页
Journal of Modern Oncology
基金
内蒙古卫生厅基金资助项目(编号:2010280)
关键词
局部晚期宫颈癌
多西紫杉醇
顺铂
同期放化疗
local advanced cervical cancer
cisplatin
docetaxel
concurrent chemotherapy and radiotherapy
