摘要
新生儿缺氧缺血性脑损伤是我国新生儿急性死亡和慢性神经系统后遗症的重要原因之一。目前新生儿缺氧缺血性脑药物治疗效果不佳,主要原因是药物无法通过血脑屏障。蛋白质转导结构域(prote in transduction domain,PTD)是指一类能携带其他生物大分子(蛋白多肽、DNA、寡核苷酸等)穿过多种哺乳动物细胞并使其在细胞内积聚的小分子阳离子多肽。PTD能携带生物大分子物质透过血脑屏障(Blood-Brain Barrier,BBB),这为我们研究、治疗中枢神经系统(Central Nervous System,CNS)疾病提供了新的思路。本文就PTD的结构特征、转导过程、与物质连接方式、CNS疾病治疗现状等方面来阐述PTD在新生儿缺氧缺血性脑病中的应用前景。
Hypoxic-ischemic brain damage was an important reason that cause acute death and chronic nervous system sequelae in our country currently.The medicine cure was not effective for hypoxic-ischemic brain damage,the main reason was that cerebral medicine can not pass blood-brain barrier.The protein transduction domain was referred to one kind of small molecular positive ion multi-peptides that be able to carry other biological macromolecule（protein multi-peptides,DNA,widowed nucleotide and so on） through many kinds of mammal＇s cells and cause it agglomerating in the cell.This transportation carrier can carry the biological macromolecule material through the blood brain barrier,which provided us with new mentality of studying,treating central nervous system illness.This article elaborated prospect of application PTD to hypoxic-ischemic brain damage from the PTD＇s structural feature,transduction process,material connection mode,present situation of treatment on CNS illness.
出处
《中华全科医学》
2011年第10期1602-1604,共3页
Chinese Journal of General Practice
基金
安徽省教育厅课题(KJ2010B112)
关键词
蛋白转导
HIBD
血脑屏障
Protein transduction
HIBD
Blood brain barrier
