摘要
目的研究孝感地区儿童呼吸道流感嗜血杆菌感染现状及耐药性,为临床抗感染治疗提供依据,以便有效指导临床合理用药。方法对孝感市中心医院2008年1月-2010年1月儿科门诊及住院患儿呼吸道感染患儿的鼻咽分泌物及深部吸痰,进行细菌培养,菌种鉴定,并用K-B法进行药敏试验,头孢硝噻酚试验检测β-内酰胺酶。结果 2年间共分离出H i 92株,对氨苄西林、复方新诺明、氯霉素的耐药率较高,分别为43.5%、57.6%、26%,对左氧氟沙星、环丙沙星、阿奇霉素、头孢噻肟、头孢呋辛、氨苄西林/舒巴坦的敏感性均较高,耐药率分别为3.3%、4.3%、2.2%、4.3%、8.7%、8.7%,均小于10%,产酶率为32.6%。结论孝感地区儿童呼吸道流感嗜血杆菌耐药形势较为严峻,产酶率较高,应引起临床高度重视。治疗以二、三代头孢菌素及其复合制剂为首选。
Objective To investigate the infections state and antibiotic resistance of Haemophilus influenza in children with respiratory tract infection in Xiaogan,so as to provide basis for medical treatment and to guide the reasonable use Haemophilus influenza in clinic.Methods The specimens of clinical sputum and swabes samples from children outpatient and be hospitalized with respiratory tract infection were collected,incubated and identified from January 2008 to January 2010 in Xiaogan.Drug susceptibility test was conducted by kirby-bauer method.Nitrocefin slip test was applied to detect β-lactamase.Results Totally 92 Haemophilus influenza strains were isolated during 2008-2010.The resistance rate to ampicillin,smz＋tmp,chloramphenicol,levofloxacin,ciprofloxacin,azithromycin,cefotaxime,cefuroxime,ampicillin/sulbactam were 43.5%,57.6%,3.3%,26%,4.3%,2.2%,4.3%,8.7%,and 8.7% respectively.The prevalence of β-lactamase was 32.6%.Conclusion The high drug antibiotic resistance and β-lactamase positive rate of Haemophilus influenza isolated from respiratory tract infection of children by multi-resistance in Xiaogan were serious.It must be paid highly attention by clinicians.The use of the second,third generation of cephalosporin and β-lactamase was the first choice of treatment.
出处
《中华全科医学》
2011年第10期1549-1550,共2页
Chinese Journal of General Practice
关键词
流感嗜血杆菌
呼吸道感染
儿童
耐药性
Haemophilus influenza
Respiratory tract infection
Children
Antibiotic resistance
