摘要
目的观察抗菌素与益生菌制剂序贯治疗腹泻型肠易激综合征(D-IBS)患者的疗效。方法将86例患者分为3组,A组给予抗菌素、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗1周,继之以双歧三联活菌胶囊、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗7周;B组进行菌剂治疗,应用双歧三联活菌胶囊、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗8周;C组进行一般治疗,应用匹维溴铵、复方谷氨酰胺肠溶胶囊治疗8周。记录治疗前后各组消化道症状评分。结果各组治疗中及治疗后较入组时腹痛持续时间明显缩短,腹痛频率明显下降,大便性状异常比例和排便异常比例下降。治疗前3组消化道评分均较高,治疗1周后开始下降,第4周时症状评分值下降较明显,组间比较差异有统计学意义,并维持到停药4周,A组优于B、C组。结论序贯治疗、菌剂治疗和一般治疗组均能缓解D-IBS患者的下消化道症状,但序贯治疗组缓解作用更明显,且维持缓解的时间更长。
Objective To explore the effects of sequential treatment with antibiotics-probiotics in patients with diarrhea-predominant irritable bowel syndrome.Methods All of 86 patients with D-IBS were divided into 3 groups.The patients in Group A received ＂sequential treatment＂ with antibiotics,Pinaverium Bromide and Glutamine enteric-coated capsules in the first week,and then followed with Pinaverium Bromide and Glutamine enteric-coated capsules and probiotics for another 7 weeks.The patients in Groups B received treatment with Pinaverium Bromide,Glutamine enteric-coated capsules and probiotics for 8 weeks.The patients in Groups C received treatment with Pinaverium Bromide and Glutamine enteric-coated capsules for 8 weeks.The gastrointestinal symptom scores were documented respectively before and after the treatment.Results The duration of abdominal pain during and after the treatment were shortened significantly when compared to those prior to the treatment,the frequency of abdominal pain and the proportion of abnormal stool decreased significantly in all the groups during and after the treatment.The lower GI symptom score of three groups decreased significantly in the 4th week,the scores of Group A was significantly lower than that of Group B and C.And the effect maintained for 4 weeks after the drug withdrawal.Conclusion All the treatments greatly improved the lower GI symptoms in D-IBS suffers.However,the sequential treatment was better in relieving the lower GI symptoms comparing with adjusted treatment and general treatment,and maintained remission longer.
出处
《中华全科医学》
2011年第10期1534-1535,共2页
Chinese Journal of General Practice
关键词
腹泻型肠易激综合征
抗菌素
益生菌
Diarrhea-predominant irritable bowel syndrome
Antibiotics
Probiotic
