摘要
狂犬病病毒感染机体后可引起严重的脑炎,病死率几乎为100%。暴露前预防免疫和及时的暴露后免疫可有效阻止脑炎的发生,一旦出现狂犬病临床症状后,几乎所有的治疗方法均无效。病毒感染机体后,激发机体产生先天性和获得性免疫应答,而在病毒进入中枢神经系统前,机体产生的免疫应答不足可能是免疫保护失败的原因之一。本文综述了机体对狂犬病病毒感染与疫苗免疫产生的免疫反应。
Rabies virus causes encephalitis in humans with a fatality rate of almost 100%.Encephalitis can be effectively prevented by pre-exposure vaccination and prompt post-exposure vaccination.However,almost all methods of treatment are ineffective once the clinical symptoms of rabies develop.Innate and adaptive immune responses are triggered once the body is infected with the pathogen.An inadequate adaptive immune response triggered by the virus,particularly before the virus enters the CNS,may be one of the reasons for failed immunoprotection in humans.This paper reviews the immune response to rabies infection and vaccination.
出处
《中国病原生物学杂志》
CSCD
2011年第8期614-617,共4页
Journal of Pathogen Biology
基金
国家重点基础研究发展计划(No.2011CB504706)
公益性行业(农业)科研专项(No.201103032)
关键词
狂犬病病毒
免疫反应
免疫抑制
综述
Rabies virus
immune response
immunosuppression
review
