摘要
目的:探讨胸腔内注入尿激酶对金葡素治疗晚期非小细胞肺癌所致多房性包裹性恶性胸腔积液疗效的影响。方法:将39例晚期非小细胞肺癌合并多房性包裹性恶性胸腔积液的患者,随机分为治疗组和对照组。治疗组20例患者胸腔应用尿激酶后充分引流胸腔积液,再行胸腔注射金葡素治疗;对照组19例患者直接引流胸腔积液后于胸腔注射金葡素治疗。同时,2组患者均采用长春瑞滨+顺铂化疗。观察2组患者的疗效和胸腔积液控制时间,并记录不良反应。结果:治疗组胸腔积液控制总有效率为85.0%,对照组为47.4%,治疗组显著高于对照组(P<0.05)。胸腔积液控制时间治疗组较对照组显著缩短(P<0.05)。结论:胸腔内注入尿激酶明显提高了金葡素治疗晚期非小细胞肺癌所致多房性包裹性恶性胸腔积液的有效率,且显著缩短了胸腔积液的控制时间。
OBJECTIVE：To investigate effects of intrapleural injection of urokinase on the therapeutic efficacy of Staphylococcus aureus enterotoxin in the treatment of multilocular encapsulated malignant pleural effusion.METHODS：39 patients with advanced non-small cell lung cancer complicating with muhilocular encapsulated malignant pleural effusion were randomly divided into treatment group and control group.20 patient in treatment group were firstly treated with intrapleural injection of urokinase,so that the smooth drainage of pleural effusion as far as possible to do.Then the treatment of intrathoracic Staphylococcus aureus enterotoxin was continued.19 patients in control group were directly treated with intrathoracic Staphylococcus aureus enterotoxin after drainage of pleural effusion.Adverse drug reactions of 2 groups were recorded.RESULTS：Total effective rate of pleural fluid control were 85.0% in treatment group and 47.4% in control group.Total effective rate of treatment group was significantly higher than that of control group（P0.05）.Compared with control group,the time of controlling pleural fluid was significantly decreased in treatment group（P0.05）.CONCLUSION：Intrapleural injection of urokinase has improved the effective rate of multilocular encapsulated malignant pleural effusion treated with Staphylococcus aureus enterotoxin,and has decreased the time of controlling pleural fluid significantly.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第36期3404-3406,共3页
China Pharmacy
关键词
尿激酶
金葡素
多房性包裹性恶性胸腔积液
Urokinase
Staphylococcus aureus enterotoxin
Mutilocular encapsulated malignant pleural effusion
