摘要
本文应用透射电镜(TEM)对21例各种类型白血病患儿的白血病细胞的超微结构进行了观察,发现各型白血病细胞具有共同的超微结构的异常变化,如均出现核泡、核内假包涵体、核内小体及线粒体的结构破坏等,亦观察到可作为各类型白血病鉴别特征的各自特殊的形态表现,并见到两种不同结构的病毒样颗粒及一些白血病细胞的少见表现,如颗粒型急淋及急淋白血病细胞中的包绕核染色质的核泡(Sep-aration)。初步探讨了用透射电镜观察白血病细胞的意义。
Ultrastruetural study of transmission electron microscope(TEM)was performed on the leukemic cells in 21 children with leukemia.We observed that all types of leukemic cells have common abnormal changes, such as the presence of nuclear blebs,pseudoinclusions,nucleosomes,disrupted mitochondrias,and each type of leukemia has its special features which enable to differentiate from each other.We also noticed two types of virus—like particles and some unusual manifestations of leukemic cells,e,g.granular acute lymphoblastic leukemia and areas of chromatin demarcated from the rest of the nucleus(separations)in acute lymphoblas- tic leukemia.The ultrastructural diagnostic significance in differentiating several kinds of leukemic cells was preliminarily discussed.
关键词
白血病细胞
透射电镜
超微结构
transmission electron microscopy
leukemic cells
ultrastructure
