摘要
目的观察舒肝调经方治疗多囊卵巢综合征(PCOS)伴情志障碍患者的临床疗效。方法收集PCOS伴情志障碍患者90例,随机分为中药组和对照组各45例,对照组给予达英-35和克罗米芬治疗,中药组在对照组基础上加用舒肝调经方治疗,21天为1个疗程,共3个疗程。分别于治疗前后测定黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、催乳素(PRL)、睾酮(T)水平;分别于治疗前、治疗后4、8、12周末采用抑郁自评量表(SDS)、焦虑自评量表(SAS)进行评分;采用简明健康状况调查表(SF-36)观察患者的生存质量。于治疗结束后6个月观察患者的排卵率、妊娠率及流产率。结果中药组总有效率84.4%,对照组总有效率62.2%,中药组疗效优于对照组(P<0.05);中药组激素水平明显改善,治疗后12周SDS、SAS评分均低于对照组(P<0.05);治疗后中药组在生理角色、躯体疼痛、总体健康、活力、情感角色和心理健康方面评分均较治疗前提高(P<0.05);两组患者排卵率、妊娠率及流产率的比较差异无统计学意义(P>0.05)。结论舒肝调经方治疗P-COS伴情志障碍患者可提高其总体疗效,改善患者生存质量。
Objective To observe the clinical effect of Shugan Tiaojing Formula （Formula to relieve the liver stagnation and regulate menstruation） on the polycystic ovarian syndrome （PCOS） patients accompanied with emotional disturbance. Methods Ninety PCOS patients with emotional disturbance were collected and randomized into Chinese medicine group and control group with 45 in each. The control group was administered Diane-35 and Clomiphene, based on which, the Chinese medicine group was given Shugan Tiaojing Formula additionally, 21 days as one course, totally 3 courses. Before and after treatment, the hormone levels including luteotropic hormone （LH）, follicle stimulating hormone （FSH）. estrodiol （E~）. prolactin （PRL） and testosterone （T） were determined. Before treatment and 4, 8, and 12 weeks after treatment＇ the self-rating depression scale （SDS） and self-rating anxiety scale （SAS） were applied for scoring. The 36-item shot-form health status survey （SF-36） was used to observe the life quality of patients. And 6 months after treatment, the ovulation rate＇, pregnancy rate and spontane- ous abortion rate were observed. Results The total effective rate in the Chinese medicine group and control group was 84.4% and 62.2% respectively, the difference was significant （P^0.05）. The hormone level of the Chinese medicine group was sig- nificantly improved, and the SDS and SAS scores 12 weeks after treatment were lower than those of the control group （P〈 0. 05）. After treatment, the Chinese medicine group was improved in the scores of physiological role, somatalgia, overall health and vitality, emotional role, and psychological health （P〈0.05）. The ovulation rate, pregnancy rate, and spontaneous abortion rate of the two groups were not statistically different （P〈0. 05）. Conclusion Shugan Tiaojing Formula is effective in enhancing the overall effect and improving the life quality of PCOS patients with emotional disturbance.
出处
《中医杂志》
CSCD
北大核心
2011年第17期1479-1482,共4页
Journal of Traditional Chinese Medicine
关键词
舒肝调经方
情志障碍
多囊卵巢综合征
生存质量
Shugan Tiaojing Formula （Formula to relieve the liver stagnation and regulate menstruation）
emotional disturb-ance
polycystie ovarian syndrome （PCOS）
quality of life
