摘要
脓毒症与非感染性全身炎性反应综合征有着相似的临床表现,早期诊断脓毒症至关重要。脓毒症诊断中常用的生化标志物C反应蛋白是非特异性炎症指标,白细胞介素6是重要的细胞因子,在脓毒症时升高,但特异性不高。降钙素原在脓毒症中的诊断价值存在争议,B型尿钠肽前体N末端水平在严重脓毒症时可作为一个早期心功能障碍和心肌抑制有用的生物指标。肾上腺髓质素前体中段、内皮素1前体、髓样细胞触发受体(TREM-1)是新近发现的炎症指标,尤其是sTREM-1可能成为诊断脓毒症最有前途的生化标志物。
It is important to diagnose sepsis in the early stage,while there are similar clinical manifestations of sepsis and non-infectious systemic inflammatory response syndrome.There are some biomarkers in the diagnosis of sepsis.The C-reaction protein is a non-specific inflammation indicator and IL-6 is an important cytokine which increases during sepsis,but with low specificity.The value of procalcitonin is still controversial.NT-proBNP can be used as a marker in heart dysfunction during sepsis.MD-proADM,proET-1 and soluble triggering receptor expressed on myeloid cells-1（TREM-1）are new biomarkers in sepsis,especially sTREM-1,which may be the most hopeful biomarker in the diagnosis of sepsis.
出处
《医学综述》
2011年第15期2256-2258,共3页
Medical Recapitulate
基金
天津市卫生局科技基金(09KZ93)
