摘要
目的:探讨尿钠素(URO)对2型糖尿病(DM2)早期肾小管损伤筛选的价值。方法:采用放免法检测正常对照组(41例)、DM2无肾病组(33例)、DM2早期糖尿病肾病(DN)组(37例)和DM2合并肾病组(26例)尿液中的URO,分析各组间URO水平的变化并与尿微量白蛋白与尿肌酐比值(mA/UCr)进行相关分析。URO诊断性能采用受试者工作特征(ROC)曲线进行分析。结果:在DM2无肾病组、早期肾病组和合并肾病组间,随着肾损伤程度的加深,患者尿URO的浓度出现显著性的减低(P<0.001);URO与mA/UCr间相关性分析显示,存在良好的负相关关系(r=-0.626,P<0.01)。而且在DM2早期阶段,URO在ROC曲线的线下面积为0.759,取临界值≤51.5pg/ml时,其敏感性与特异性分别为67.14%和70.29%,与mA/UCr有相近的诊断效率。结论:尿液中URO排泄下降能特异性地反映DM2早期肾小管的损伤,并可作为重要的评估参数。
Objective To investigate the clinical application of urodilatin（URO） in tubular injury of DM2.Methods 41 healthy controls,33 type 2 diabetics without nephropathy,37 patients with early stage of diabetic nephropathy and 26 patients with clinical diabetic nephropathy were enrolled in the study and categorized into four groups.Urodilatin was measured by radioimmunoassay（RIA）.The changes of urodilatin levels among four groups were analyzed,and correlation analyses were performed between urodilatin and urinary micro-albumin/urine creatinine（mA/UCr）.The efficiency index of URO were evaluated by receiver operation characteristic（ROC）.Results Compared with those in the controls,diabetics without nephropathy,early stage of diabetic nephropathy and clinical diabetic nephropathy,the urodilatin level decreased significantly in the course of diabetic nephropathy（P0.001）.The value of URO was significantly correlated with mA/UCr（r=-0.626,P0.01）.In early phase of DM2,The area under curve was 0.759.When the cut-off vaule of URO was ≤51.5pg/ml,The sensitivity and specificity were 67.14% and 70.29%,respectively.Furthermore,Urodilatin had similar diagnosis efficiency with mA/UCr.Conclusion The decrease of urodilatin level had clinical value in pristine tubular injury of DM2 and can serve as an evaluation parameter.
出处
《放射免疫学杂志》
CAS
2011年第4期372-374,共3页
Journal of Radioimmanology
