摘要
目的探讨提高宫颈癌前病变及宫颈癌筛查的检出率最有效的途径。方法随机抽取我院门诊就诊患者行细胞学筛查(TCT)及DNA倍体分析。细胞学诊断采用TBS分级系统。细胞学诊断阳性者,全部在阴道镜下取活组织检查。所有检查均在双盲下进行。结果 TCT异常者检出率为8.43%(191/2267)。其中,非典型鳞状上皮细胞(ASCUS)检出率为5.03%(114/2267),低度鳞状上皮内病变(LSIL)1.72%(39/2267),高度鳞状上皮内病变(HSIL)1.59%(36/2267),宫颈鳞状细胞癌(SCC)0.09%(2/2267)。DNA倍体分析异常101例(4.46%)。结论 TCT联合应用DNA定量分析,能提高宫颈癌前病变及宫颈癌筛查的特异性和检出率。
Objective To investigate an effective approach to improve detection rate for screening the cervical precancerous lesions and cervical cancer.Methods The TCT analysis,DNA ploidy analysis and TBS cytology grading system were used to screen the wemen coming to our gynacological clinic.The cytologically positive patients underwent cervix biopsy under colposcopy.All examinations were carried out under double-blind.Results The detection rate of TCT abnormalities was 8.43%（191/2267）,of which that of ASCUS was 5.03%（114/2267）,LSIL 1.72%（39/2267）,HSIL 1.59%（36/2267） and SCC 0.09%（2/2267）.The abnormal DNA ploidy analysis occurred in 101 cases（4.46%）.Conclusion Cervical cytology screening combined with quantitative DNA analysis may improve the detection rate of cervical precancerous lesions and early cervical carcinoma.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第16期1901-1903,共3页
Jiangsu Medical Journal
基金
湖北医药学院中青年基金项目(2009ZQN1)
关键词
液基细胞学检查
宫颈癌
DNA倍体分析
Liquid-based cervical cytology
Cervical cancer
DNA ploidy analysis
