摘要
目的探讨双酚A对成年雄性小鼠食物利用率的影响。方法 100只成年雄性ICR小鼠随机分为阴性对照组、己烯雌酚对照组、双酚A 2、20、100 mg/(kg·d)组,各组每天给予相应剂量受试物灌胃2周,之后再观察6周。实验期间每周称量各组动物体质量1次,每天称量各组动物摄取生长繁殖颗粒饲料的重量。结果给予双酚A 8周后,各组动物体质量差异无统计学意义(P>0.05);给予双酚A的第2周,2,20,100 mg/(kg.d)双酚A组动物的食物利用率与阴性对照组比较明显升高(P<0.01);第4周,20,100 mg/(kg·d)双酚A组动物的食物利用率与阴性对照组比较明显升高(P<0.05);第6周,100 mg/(kg·d)双酚A组动物的食物利用率与阴性对照组比较明显升高(P<0.05);第8周,所有双酚A组动物的食物利用率与阴性对照组比较差异无统计学意义(P>0.05)。结论 双酚A对于成年雄性ICR小鼠的食物利用率有增高作用。
Objective To investigate the effect of bisphenol-A on food utilization rate in adult male mice.Methods A total of 100 adult male ICR mice were randomly divided into groups of negative control,20 mg/kg diethylstilbestrol control,and 2,20 and 100 mg/kg bisphenol-A treatment,respectively.Mice of each group were treated with relative material once per day by intragastric administration for two weeks and observed for six weeks after treatment.The weight of mice was observed by weekly measurement and the weight of food intake was taken by daily recording.Results There was no significantly difference in body weight among all groups in the sixth week after bisphenol-A treatment.Food utilization rate was higher in the groups of 2,20 and 100 mg/kg bisphenol-A treatment than in negative control group with two weeks of bisphenol-A treatment（P0.01）.Food utilization rate was still higher in the groups of 20 and 100 mg/kg bisphenol-A treatment than in negative control group in the second week after bisphenol-A treatment（P0.05）.Food utilization rate was higher only in 100 mg/kg bisphenol-A group than in negative control group in the forth week after bisphenol-A treatment（P0.05）.There was no significantly difference in food utilization rate between bisphenol-A groups and negative control group in the sixth week after bisphenol-A treatment.Conclusion Bisphenol-A could enhance food utilization rate in adult male ICR mice.
出处
《中国预防医学杂志》
CAS
2011年第8期686-688,共3页
Chinese Preventive Medicine
基金
浙江医学高等专科学校科研基金项目(2009XX022008B002)
浙江省大学生科技创新基金项目(2008R434003)
浙江省高职高专2010年第一批示范性实训基地建设项目(基层公共卫生实训基地)
关键词
双酚A
体质量
食物利用率
Bisphenol-A
Body weight
Food utilization rate
