摘要
目的:探讨DcR3在SLE免疫紊乱过程中发生的变化及其可能作用机制。方法:选择36例SLE患者,以12例健康体检者为对照;采用ELISA法检测血清中的DcR3I、L-4和IFN-γ。结果:SLE组血清DcR3I、L-4和IFN-γ量显著高于正常对照组(P均<0.01);SLE患者中I,FN-γ/IL-4值呈两极化分布特点,以0.76为界,分为较明显的高值组(n=19,1.93±1.14)和低值组(n=170,.53±0.09)I,FN-γ/IL-4低值组的DcR3和IL-4水平比IFN-γ/IL-4高值组和正常对照组均高;DcR3与IL-4呈正相关趋势(r=0.340,P<0.05),与IFN-γ/IL-4呈负相关趋势(r=-0.332,P<0.05)。结论:SLE患者血清DcR3水平显著升高,可能通过促Th2等作用参与SLE的发生发展。
Objective：To explore the alternation of decoy receptor 3（DcR3） and its mechanism of action in the immune pathogenesis of patients with systemic lupus erythematosus（SLE）.Methods：36 patients with SLE and 12 healthy volunteers as controls were included in the study.Their serum levels of DcR3,IL-4 and IFN-γ were determined by enzyme linked immunosorbent assay（ELISA）.Results：Significantly higher serum of DcR3,IFN-γ and IL-4 concentrations（P0.01）were detected in SLE patients than the healthy volunteers（P0.01）.In SLE patients,IFN-γ/IL-4 ratio displayed a polarized distribution,and the SLE patients could be divided into hypso-ratio group（n=19,1.93±1.14）and hypo-ratio group（n=17,0.53±0.09）with the cut-point of 0.76.And the levels of DcR3 and IL-4 of hypo-ratio group were higher than both the hypso-ratio group and control group.DcR3 correlated positively with IL-4（r=0.340,P0.05）and negatively with IFN-γ/IL-4 ratio（r=-0.332,P0.05）.Conclusion：The data showed that serum DcR3 concentrations in patients with SLE were significantly elevated.And DcR3 might play important roles in the development of SLE by promoting T helper cells transforming into Th2 cells.
出处
《中国卫生检验杂志》
CAS
2011年第8期1928-1930,共3页
Chinese Journal of Health Laboratory Technology
