摘要
目的探讨64层螺旋CT灌注成像在评价星形细胞肿瘤血管生成中的临床应用价值。方法对26例经手术病理证实的星形细胞肿瘤患者术前行64层螺旋CT灌注扫描,测量肿瘤的各项血流灌注指标;免疫组织化学染色SP法检测肿瘤的微血管密度(MVD)和血管内皮生长因子(VEGF)表达水平。结果①高级星形细胞肿瘤组的脑血流量(BF)、血容量(BV)、表面通透性(PS)、MVD及VEGF表达均较低级星形细胞肿瘤组明显升高,两者比较差异均有统计学意义(P<0.05或P<0.01);②星形细胞肿瘤的CT灌注参数BF、BV、PS值分别与MVD、VEGF表达呈显著正相关(P均<0.01)。结论 CT灌注成像可准确反映星形细胞肿瘤瘤体内血管生成,有助于临床制定治疗方案,判断疗效及预后。
Objective To investigate the value of 64-slice spiral CT perfusion imaging in evaluating the angiogenesis of astrocytoma.Methods Twenty-six patients confirmed astrocytoma by operation and pathology were examined by 64-slice spiral CT perfusion imaging,and the perfusion parameters were measured.MVD and expressions of VEGF were examined immunohistochemically using SP techniques.Results ①MVD,VEGF and the values of BF,BV,PS of the high-grade astrocytoma were higher than those of low-grade astrocytoma.There were statistically significant differences between the two groups(P〈0.01 or P〈0.05).②The BF,BV and PS value of astrocytoma had obviously positive correlation with MVD and VEGF correspondingly(all P〈0.01).Conclusion CT perfusion imaging can accurately reflect the angiogenesis of astrocytoma in vivo,which will be helpful to optimize the treatment protocol and to predict the patient's prognosis.
出处
《临床医学》
CAS
2011年第6期27-30,共4页
Clinical Medicine