摘要
目的观察30岁以下既往无糖尿病的非酒精性脂肪性肝病男性患者口服糖耐量试验,预测NAFLD与临床前期糖尿病的相关性。方法选择52例合并丙氨酸氨基转移酶升高的NAFLD年青男性患者,所有患者均行75g标准口服糖耐量实验,空腹血糖受损是指空腹血糖水平≥6.1mmol/L但<7mmol/L,糖耐量异常是指餐后2h血糖水平≥7.8mmol/L但<11.1mmol/L。结果 11(21%)名患者被诊断为空腹血糖受损,18(35%)名患者被诊断为糖耐量异常,6(12%)名患者被诊断为糖尿病,17(33%)名患者糖耐量正常。与糖代谢正常的NAFLD患者相比,体重指数、腰围、转氨酶水平、总胆红素、总胆固醇、甘油三酯、空腹血糖、HOMA-IR均有显著差异。结论建议对合并丙氨酸氨基转移酶升高的非酒精性脂肪肝患者,即使是年青病人,亦应行口服糖耐量实验来预测2型糖尿病的危险性。
Objective This study was designed to determine the relationship between non alcoholic fatty liuer disease（NAFLD） and the oral glucose tolerance test（OGTT） to predict preclinical diabetes in nondiabetic young male patients（30 years old）.Methods A total of 52 young male patients who had elevated alanine aminotransferase and who were diagnosed with NAFLD were enrolled in this study.A standard 75 g OGTT was carried out on all patients.Impaired fasting glucose（IFG） and impaired glucose tolerance（IGT） were defined as a fasting plasma glucose（FPG） level ≥6.1mmol/L but 7mmol/L,and a 2～h post-load glucose on the OGTT of ≥7.8mmol/L,but 11.1mmol/L respectively.Results According to the OGTT results,11（21%） patients were diagnosed as having IFG,18（35%） patients were diagnosed as having IGT and 6（12%） patients were diagnosed as having diabetes.17（33%） patients showed normal glucose tolerance.The NAFLD patients with abnormal glucose tolerance showed significant differences in body mass index,waistlines,alanine aminotransferase,total bilirubin,total cholesterol,triglyceride,FPG and homeostasis model for insulin resistance（HOMA-IR）.Conclusions Although the patients were young,an OGTT should be recommended for male NAFLD patients with elevated liver enzymes to predict the risk of type 2 diabetes.
出处
《医药论坛杂志》
2011年第13期24-26,共3页
Journal of Medical Forum
