摘要
目的观察血液灌流治疗新生儿高胆红素血症的疗效和安全性。方法选择2007年1月至2008年12月新生儿重症高胆红素血症19例,采用内科常规治疗联合HA230型树脂血液灌流器进行血液灌流,比较灌流前后患儿的症状、体征、肝功能、血常规和血生化指标的变化情况,监测灌流过程中的不良反应。结果灌流后患儿的临床症状、体征均有不同程度的改善,总胆红素、间接胆红素、直接胆红素、丙氨酸氨基转移酶(ALT)、天门氨酸氨基转移酶(AST)、ALB(白蛋白)、血小板和iCa2+较灌流前均明显下降,差异有统计学意义(P<0.05);红细胞、白细胞、血钠、血钾、血葡萄糖(Glu)灌注前后差异无统计学意义(P>0.05);整个灌流过程中无严重不良反应发生。结论 常规治疗联合血液灌流治疗重症新生儿高胆红素血症有较好的疗效和安全性。
Objective To observe the efficacy and safety of hemoperfusion for neonatal hyperbilirubinamia.Methods Nineteen patients of neonatal hyperbilirubinamia in our hospital from Jan 2007 to Dec 2008 received the treatment with HA neutral macroporous resin（HA230） hemoperfusion and medical treatment.Symptoms,signs and levels of liver function,complete blood counts were compared before and after treatment.Adverse reaction of hemoperfusion was also monitored.Results After hemoperfusion,the symptoms and signs were improved in certain degrees.The levels of total bilirubin,indirect bilirubin,direct bilirubin,platelet and iCa2＋decreased significantly compared with those before hemoperfusion（P0.05）.There were no significant differences in the levels of erythrocyte,leukocyte,K＋,Na＋ and blood glucose before and after hemoperfusion（P0.05）.No adverse effect occurred in the whole process of hemoperfusion.Conclusion Hemoperfusion is an effective and safe therapy for neonatal hyperbilirubinamia.
出处
《实用医院临床杂志》
2011年第5期145-147,共3页
Practical Journal of Clinical Medicine
