摘要
目的探索银屑病皮损组织中梅克尔细胞表达角蛋白(CK20、CK19、CK18)的情况及与氨基肽酶N(CD13)表达的关系,探讨银屑病的发病机制。方法采用免疫组化方法,检测寻常型银屑病患者皮损组织中梅克尔细胞表达CK20、CK19、CK18的情况和表皮层CD13表达的情况,分析CK20、CK19和CK18与CD13表达的关系,并与正常人对比。结果与正常人比较,皮损组织中CK20、CK19、CK18和CD13的表达均升高(P<0.01)。CK20、CK19和CK18与CD13的表达呈正相关,相关系数分别为0.856、0.838、0.820(P<0.01)。结论银屑病皮损组织中Merkel细胞变化在银屑病发病中可能发挥一定的作用。
Objective To investigate the expression of three cytokeratins（CK20,CK19,CK18）in Merkel cells and their relations with aminopeptidase N（CD13）expression in psoriatic skin lesion tissues,and to explore the pathogenesis of psoriasis.Methods Immunohistochemical method was employed to detect the expression of CK20,CK19,CK18 and CD13 in skin lesion tissues of patients with psoriasis vulgaris.The relationships among them were statistically analyzed and compared with healthy people.Results Compared with healthy controls,the expression of CK20,CK19,CK18 and CD13 increased obviously in psoriatic skin lesion tissues（P〈0.01）.The expression of CK20,CK19 and CK18 was positively correlated with CD13 expression,and the coefficient correlation was 0.856,0.838 and 0.820 respectively（P〈0.01）.Conclusion The functional changes of Merkel cells in psoriatic skin lesion tissues maybe play some roles in the pathogenesis of psoriasis.
出处
《西南国防医药》
CAS
2011年第2期134-137,共4页
Medical Journal of National Defending Forces in Southwest China
