摘要
目的观察急性脑梗死(ACI)患者早期血清C-反应蛋白(CRP)的水平变化及其与OCSP分型、梗死灶大小的关系。方法采用免疫比浊法对247例发病48h内ACI患者的血清CRP水平进行测定,按照OCSP标准对患者进行病因分型,以CT或MRI测定病灶大小,选取同期85例健康体检者为正常对照组,比较分析其临床资料。结果 ACI患者血清CRP水平与对照组比较显著升高。TACI升高最为明显,显著高于另外3个亚型。PACI较POCI和LACI显著增高,但后两者之间差别无统计学意义,血清CRP水平升高程度与梗死灶大小密切相关。结论急性脑梗死各型患者血清CRP水平不尽不同,表明其在病因及病理生理学机制方面存在着一定的差异。CRP可作为ACI患者病情评估的重要指标。
Objective To observe the changes of serum C-reactive protein （CRP） level in the patients with acute cerebral infarction （ACI） and its relationship with different subtypes （according to Oxford-shire Community Stroke Project criteria, OCSP criteria） and infarct size. Methods Serum concentrations of CRP were measured by immunoturbidimetry within 48 hours after the onset of ACI in 247 patients. All the patients were classified into four subtypes according to OCSP criteria. The infarct size was measured by CT scan or MRI.85 healthy subjects were selected as the control group. The CRP levels of different groups were compared. Results The level of serum CRP in the patients with ACI was significantly higher than those in control group. Among four OCSP subtypes, CRP level of TACI group was significantly higher than those of other groups. And POAI group has significantly higher CRP than POCI and LACI group. But there is no significant difference between POCI and LACI group. CRP levels were correlated with infarct size intimately. Conclusion CRP level were distinct among different OCSP subtypes. The changes of CRP level may reflect the etiological and pathophysiological diversity ofACI. CRP level could indicate the severity of neurological impairment in patients with ACI.
出处
《海南医学》
CAS
2011年第17期41-43,共3页
Hainan Medical Journal
关键词
C-反应蛋白
急性脑梗死
OCSP分型
C-reactive protein （CRP）
Acute cerebral infarction （ACI）
Oxford-shire Community Stroke Project （OCSP）
