摘要
目的:研究芷冰原位凝胶的体外释放行为。方法:以卡波姆为材料制备芷冰鼻腔原位凝胶,考察其中欧前胡素和异欧前胡素的体外释药行为,用Weibull方程对其体外释放结果进行拟合。结果:制备的芷冰原位凝胶体外具有缓释效果,可以持续释药8 h,释放效果随卡波姆用量的增加而降低,其释药行为符合Weibull方程。结论:芷冰原位凝胶的体外释药机制为非Fick扩散。
Objective：To investigate the release profile of Zhibing in-situ gel（ZB-ISG）in vitro.Method： ZB-ISG was prepared by Carbomer,investigated the release behavior of imperatorin and isoimperatorinin vitro,and the results were fitted by weibull equation.Result： ZB-ISG had slowly-releasing effect and could continously release for 8h,and the release effect decreases with the increase of Carbomer.The study showed that all models fitted well with Weibull equation.Conclusion： The releasing mechanism of ZB-ISG is non-Fickian diffusionin vitro.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第17期29-32,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省科技计划项目(2008B03031141)
