摘要
The internal radiation dose calculations based on Chinese models is important in nuclear medicine.Most of the existing models are based on the physical and anatomical data of Caucasian,whose anatomical structure and physiological parameters are quite different from the Chinese,may lead significant effect on internal radiation. Therefore,it is necessary to establish the model based on the Chinese ethnic characteristics,and applied to radiation dosimetry calculation.In this study,a voxel model was established based on the high resolution Visible Chinese Human(VCH).The transport procedure of photon and electron was simulated using the MCNPX Monte Carlo code. Absorbed fraction(AF)and specific absorbed fraction(SAF)were calculated and S-factors and mean absorbed doses for organs with ^(99m)Tc located in liver were also obtained.In comparison with those of VIP-Man and MIRD models, discrepancies were found to be correlated with the racial and anatomical differences in organ mass and inter-organ distance.The internal dosimetry data based on other models that were used to apply to Chinese adult population are replaced with Chinese specific data.The obtained results provide a reference for nuclear medicine,such as dose verification after surgery and potential radiation evaluation for radionuclides in preclinical research,etc.
The internal radiation dose calculations based on Chinese models is important in nuclear medicine. Most of the existing models are based on the physical and anatomical data of Caucasian, whose anatomical structure and physiological parameters are quite different from the Chinese, may lead significant effect on internal radiation. Therefore, it is necessary to establish the model based on the Chinese ethnic characteristics, and applied to radiation dosimetry calculation. In this study, a voxel model was established based on the high resolution Visible Chinese Human （VCH）. The transport procedure of photon and electron was simulated using the MCNPX Monte Carlo code. Absorbed fraction （AF） and specific absorbed fraction （SAF） were calculated and S-factors and mean absorbed doses for organs with 99mTC located in liver were also obtained. In comparison with those of VIP-Man and MIRD models, discrepancies were found to be correlated with the racial and anatomical differences in organ mass and inter-organ distance. The internal dosimetry data based on other models that were used to apply to Chinese adult population are replaced with Chinese specific data. The obtained results provide a reference for nuclear medicine, such as dose verification after surgery and potential radiation evaluation for radionuclides in preclinical research, etc.
基金
Supported by National Natural Science Foundation of China(Grant No.10875047 and Grant No.30700214)
Program for New Century Excellent Talents in University(Grant No.NCET- 10-0386)
