摘要
目的:建立适合本医院寻常型银屑病患者的药物利用评价程序。方法:收集和整理本医院皮肤科2008年1月-2010年1月25例寻常型银屑病患者的相关资料,采用药物利用评价(DUR)和药物利用评估(DUE)方法,对患者药物利用指数(DUI)、评价指标、治疗药物监测及临床治疗结果进行综合分析。结果:纳入DUI分析的药物有14种,其中有10种(占71.43%)药物DUI≤1,有4种药物DUI>1;DUE结果显示:所有患者都进行了疾病严重程度评估、肝肾功能的评估、血常规的检测。治疗药物监测指标中,肝功能和血常规监测均达到72%。药物使用频率最高的是雷公藤多苷片,其次是维生素C注射液。药品不良反应发生率最高的是肝功能异常。临床治疗结果指标均达到100%。采用2种方法评价,25例(100%)寻常型银屑病患者经治疗后临床症状均得到改善,疾病得到有效缓解。结论:联合应用DUR和DUE方法可以更全面地评价寻常型银屑病患者的用药情况。
Objective： To establish the evaluation procedure of drug utilization suitable for the patients with psoriasis vulgaris in our hospital. Methods： Data of 25 psoriasis vulgaris patients in department of dermatology in our hospital from January 2008 to January 2010 were collected. DUI, evaluation index, therapeutic drug monitoring and treatment outcome were analyzed using drug utilization reliew （DUR） and drug use evaluation（DUE）. Results： There were 14 kinds of drugs involved in DUI analysis. It showed that the DUIs of 10 drugs were less than 1, and that of 4 kinds of drugs were beyond 1. The outcomes of DUE showed that evaluation of disease severity, liver and kidney function evaluation and blood routine monitoring were examined in all 25 patients. The proportions of monitoring of liver function and blood routine which involved in therapeutic drug monitoring indexes were both of 72%. The drugs used most frequently were tripterygium glycosides, followed by vitamin C injection. Dysfunction of liver was the most common ADR. Treatment outcome indexes were all of 100%. Through evaluation by 2 methods, 25 patients with psoriasis vulgaris （100 %） improved in symptoms with alleviation in psoriasis vulgaris after treatment. Conclusion： Combination use of DUR and DUE could evaluate the medication of psoriasis vulgaris patients more comprehensively.
出处
《中国药物应用与监测》
CAS
2011年第4期235-238,共4页
Chinese Journal of Drug Application and Monitoring
