摘要
老年糖尿病患者的生理学特点,决定了他们在选择治疗药物时有其自身的特点。二甲双胍是首选的一线降糖药物;二代磺脲类药物较一代药物更为安全,在老年人中应用广泛;α-葡萄糖苷酶抑制剂和非磺脲类促泌剂有利于降低餐后血糖;老年人应用胰岛素应注意避免低血糖事件。新的降糖药物肠促胰素样物质更为安全,能减少低血糖等不良反应。老年患者的治疗应循序渐进,治疗目标需适度放宽。
The pathophysiology of geriatric diabetes gives rise to special considerations in selecting of medications. Metformin is considered as the preferred first-line glucose-lowering agent. Second-generation sulfonylureas are much safer than the first-generation products, and hence their widespread use in the elderly, α-glucosidase inhibitors and glinide drug contribute to lowered postprandial blood glucose. Particular attention should be paid to avoidance of hypoglycemia in elderly patients on insulin. Along with our deeper understanding, ineretins-like substance, as a new class of glucose-lowering agents, is much safer because of consistent efficacy and low risk of hypoglycemia. Therapy in elderly should take a progressive approach with a moderately relaxed goal of treatment.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第8期581-583,共3页
Chinese Journal of Practical Internal Medicine
关键词
老年
糖尿病
降糖药物
eldly
type 2 diabetes mellitus
medical treatment
