摘要
目的:通过高效液相色谱法,对大鼠口服阿苯达唑(ABZ)自微乳后组织分布作初步的研究。方法:高效液相色谱法,以阿苯达唑原料药和市售片剂做对照,对口服阿苯达唑自微乳浓缩液进行大鼠体内组织分布研究,考察不同制剂体内的药物分布是否有显著性差异。结果:组织匀浆液浓度测定方法的回收率均大于70%,日内、日间精密度均小于12%;自微乳在大鼠体内分布较广,与原料药及片剂相比,各组织均有不同程度的增加,其中在体内药物浓度分布趋势为肝>肺>肠>脾>肾>胃>脑。结论:与原料药和片剂比较,ABZ-SMEDDS体内分布迅速,组织分布广泛,促进了药物口服吸收,改变了ABZ在体内的组织分布。
OBJECTIVE To investigate the pharmacokinetics and tissue distribution of albendazole microemulsion in rats after oral administration by HPLC method.METHODS An HPLC method was developed for the assay of albendazole,the conventional tablet and the pharmaceutical crude drug were taken as the control.The rats＇ plasma drug concentrations and its metabolites after double doses oral administration of ABZ-SMEDDS were determined by HPLC.RESULTS The recovery was over 70%;the intra-day and inter-day RSD were less than 15%.The ABZ-SMEDDS in rats with a wide distribution,and compared with the crude drug and tablets,it had different degrees of increase in all tissues.The descending sequence of ABZ-SMEDDS levels in tissues was as follows： liver,lung,intestine,spleen,kidney,stomach and brain.CONCLUSION As compared with the conventional tablet and pharmaceutical crude drug,ABZ-SMEDDS deliver quickly and extensively to promote absorption of oral drug and improve the distribution of ABZ in tissue.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第16期1348-1351,共4页
Chinese Journal of Hospital Pharmacy
关键词
阿苯达唑
自微乳化释药系统
组织分布
albendazole
self-microemulsifying drug delivery system
tissue distribution
