摘要
目的探讨免疫球蛋白G(IgG)、轻链及尿微量清蛋白(mALB)在继发性肾病早期诊断的临床价值。方法采用BN-Ⅱ全自动蛋白分析仪分别对173例糖尿病患者、164例高血压患者、167例健康对照者进行尿IgG、mALB、κ和λ轻链测定,计算κ/λ值,并对结果进行统计学分析。结果糖尿病组和高血压组尿mALB、IgG、κ与λ轻链的水平都高于健康对照组(P<0.05),糖尿病组和高血压组κ/λ值与健康对照组的差异均无统计学意义(P>0.05)。结论尿mALB、IgG、κ与λ轻链在继发性肾病早期诊断中具有临床应用价值,κ/λ值的诊断意义则有待进一步研究。
Objective To explore the clinical value of urinary immunoglobulin G（IgG）,light chains and microalbumin（mALB） for the early diagnosis of secondary kidney diseases.Methods 173 cases of patients with diabetes mellitus（DM）,164 with hypertension and 167 cases of healthy controls were enrolled and detected for the concentration of urinary IgG,mALB,κ and λ chain by using BN-Ⅱ analyzer,and the ratio of κ/λ was calculated.All data were statistically analyzed.Results The levels of urinary IgG,mALB,κ and λ chain of DM group and hypertension group were higher than control group（P〈0.05）,but there was no statistical difference of the ratios of κ/λ between the former two groups and control group（P〉0.05）.Conclusion There was certain clinical value of urinary IgG,mALB,κ and λ chain for the diagnosis of secondary kidney diseases and the diagnostic value of the ratio of κ/λ should be further explored
出处
《国际检验医学杂志》
CAS
2011年第12期1287-1288,共2页
International Journal of Laboratory Medicine
关键词
肾病
早期诊断
尿微量蛋白
nephrosis
early diagnosis
microalbumin
