摘要
目的:对比腹腔镜手术和传统开腹结肠癌根治术中腹腔内肿瘤细胞脱落的差异,探讨腹腔镜结肠癌根治术对腹腔脱落肿瘤细胞的影响。方法:将2010年4月至2011年2月60例结肠癌患者分为腹腔镜组和开腹组,每组30例。进腹后和关腹前分别注入500 ml生理盐水灌洗腹腔。对比分析两种术式腹腔灌洗液标本肿瘤细胞的阳性检出率及腹腔灌洗液中的癌胚抗原(carcinoembryonic antigen,CEA)。结果:腹腔镜组阳性标本11例,阳性率36.7%;开腹组阳性标本20例,阳性率66.7%,两组差异有统计学意义(P=0.020)。术后两组患者腹腔灌洗液CEA值均有不同程度地增加,腹腔镜组明显低于开腹组(P=0.008)。结论:腹腔镜结肠癌手术在无瘤技术方面具有可行性和优越性,腹腔镜结肠癌根治术在关腹前需行有效的腹腔冲洗。
Objective： To evaluate the influence of the laparoscopic radical resection for colon cancer on exfoliation of cancer cells through comparing the laparoscopic and conventional laparotomy surgery. Methods：From Apr.2010 to Feb.2011,60 patients with colon cancer were equally divided into laparoscopic and open group.After advancing into and before suturing peritoneum,500 ml isotonic sodium chloride solution was infused into abdominal cavity for lavage.The positive rate of tumor cells and carcinoembryonic antigen（CEA） values in abdominal lavage fluid were compared between the 2 groups. Results：Exfoliated malignant cells were demonstrated in 11 samples of the laparoscopic group（36.7%）,and in 20 samples of the open group（66.7%）.The positive rate was significantly different between the 2 groups（P=0.020）.Postoperative CEA value both increased to some extent,and the laparoscopic group increased less than the open group（P=0.008）. Conclusions：Laparoscopic surgery for colon cancer is feasible and predominant for tumor-free technology.The abdomen must be lavaged before closure.
出处
《腹腔镜外科杂志》
2011年第8期617-619,共3页
Journal of Laparoscopic Surgery
关键词
腹腔镜检查
结肠肿瘤
腹腔灌洗
癌胚抗原
脱落肿瘤细胞
Laparoscopy
Colon neoplasms
Abdominal carity lavage
Carcinoembryonic antigen
Exfoliated tumor cells
