摘要
组蛋白翻译后修饰可影响特定基因的表达,从而在多个生理过程中发挥重要作用,是当前生命科学领域的研究热点之一。组蛋白去甲基化酶JMJD1A可催化一甲基化和二甲基化的H3K9(H3K9me1/2)去甲基化,通过解除组蛋白抑制效应而调节基因表达。JMJD1A拥有广泛的生物学功能,参与多种生物学过程包括核受体激活、精子生成、能量代谢、低氧调节和癌症发生等。本文就JMJD1A的特征及功能作一综述。
Histone post-translational modifications can affect specific genes expression,which plays an important role in many physiological processes and is one of the intense research area in current life sciences.Histone demethylase JMJD1A(Jumonji domain-containing protein 1A) regulates gene expression by catalyzingdemethylation of mono-and di-methy H3K9(H3K9me1/2).JMJD1A has important biological functions in many physiological processes,such as nuclear receptor activation,sperm development,energy metabolism,hypoxic regulation and carcinogenesis.In this review,the properties and functions of JMJD1A were discussed.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第4期484-487,共4页
Chemistry of Life
基金
国家自然科学基金资助项目(38070265)
河北省自然基金项目(C2010000410)资助
