摘要
内镜逆行胰胆管造影术(enoscopic retrograde cholangiopancreatography,ERCP)是当前诊治肝、胆、胰疾病的重要手段之一.急性胰腺炎是ERCP术后最常见、最严重的并发症,目前其发病机制仍未完全阐明.近年来研究的普遍共识是炎性细胞因子在轻症胰腺炎向重症胰腺炎演进过程中发挥了重要作用,特异性的检测指标用于预测ERCP术后胰腺炎成了研究的热点,试图通过阻断炎症级联反应的抗炎因子用于预防治疗ERCP术后胰腺炎已进入临床试验阶段,本文对这方面的研究进展作一综述.
Endoscopic retrograde cholangiopancreatography （ERCP） is an important tool for the diagnosis and treatment of pancreatobiliary disease. Acute pancreatitis （AP） is the most common complication of ERCP. The pathogenesis of postERCP AP has not been completely elucidated. Recent studies suggest that inflammatory cytokines play an important role in the evolution of AP from mild to severe form. Identification of specific proinflammatory markers that can rapidly and reliably predict the progression of post-ERCP pancreatitis has been a major focus of research. Attempts to block the inflammatory cascade have been carried out by using an antiinflammatory cytokine in some clinical trials. In this article, we will review the recent advances in understanding the role of cytokines in the pathogenesis of post-ERCP AP.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第20期2146-2152,共7页
World Chinese Journal of Digestology
关键词
细胞因子
内镜逆行胰胆管造影
急性胰腺炎
Cytokine
Endoscopic retrogradecholangiopancreatography
Acute pancreatitis
