摘要
为客观评价益气活血化瘀复方脑栓康（ 由黄芪、水蛭、葛根等中药组成） 治疗急性缺血性中风（ 脑血栓形成） 气虚血瘀证的临床疗效， 采用随机双盲对照临床试验， 将１１１ 例急性缺血性中风（ 脑血栓形成）气虚血瘀证患者随机分为两组。试验组５６ 例接受脑栓康和基础治疗， 安慰剂组５５ 例接受安慰剂和基础治疗。基础治疗包括西药脱水药（ 甘露醇和／ 或速尿） 、支持疗法， 不用抗凝及扩血管药。疗程为４ 周。结果：①试验组和安慰剂组显著进步分别为２４ ．０８％ 、５．７７ ％ ， 进步分别为７２ ．２２ ％ 、８８ ．４６％ ， 无效分别为３ ．７０ ％ 、５ ．７７％ ， 总有效率分别为９６ ．３０ ％ 、９４．２３ ％ 。两组总疗效差异有显著性（ Ｐ＜ ０ ．０５） ； 两组预期治疗（ｉｎｔｅｎｔｉｏｎ－ｔｏ－ｔｒｅａｔ） 的组间比较， 总疗效差异也有显著性（ Ｐ＜ ０ ．０５） ， 提示试验组疗效优于安慰剂组。②试验组对急性缺血性中风气虚血瘀证症状的改善比安慰剂组好（ Ｐ＜ ０ ．０１） 。③未发现脑栓康的不良反应。结果表明： 脑栓康是一种治疗急性缺血性中风（ 脑血栓形成） 气虚血瘀证的安全、有效的药物，
To observe clinical effects of Naoshuankang for acute ischemic stroke(cerebral thrombosis) with Qi-deficiency and blood-stasis syndrome, a randomized double-blinded controlled clinical trial was used in this study. One hundred and eleven cases were randomly divided into two groups, 56 cases of which were treated with Naoshuankang and basic treatment as the treatment group and 55 cases received placebo and basic treatment as control. The basic treatment included the use of dehydrating agents( e.g., mannitol and/or lasix) and supportive therapy.Neither anticoagulants nor thrombolytic agents were used in both groups. The course of treatment lasted four weeks. Results:①The remarkably effective rate in the treatment group and the control group was 24.08 % and 5.77 %,the effective rate was 72.22% and 88.46% ,the ineffective rate was 3.70% and 5.77% ,and the total effective rate was 96.30% and 94.23% respectively. The statistical analysis showed that the total effect had a significant difference between two groups (P< 0.05 ),and the total effect of intention-to-treat also showed a significant difference (P< 0.05 ).②After treatment, the relief of Qi-deficiency and blood-stasis symptoms was more marked in the treatment group than in the control group (P< 0.01 ).③No adverse effect of Naoshuankang was found. Conclusions:Naoshuankang was a safe and effective herbal medicine in treating acute ischemic stroke with Qi-deficiency and blood-stasis syndrome, and its application is worthy of further study.
出处
《广州中医药大学学报》
CAS
1999年第4期253-258,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家中医药管理局科研基金!重点课题(编号922184)
关键词
脑栓塞
中医药疗法
中风
气虚血瘀
脑栓康
CEREBRAL EMBOLISM AND THROMBOSIS/TCD therapy
STROKE/TCD therapy
QI-DEFICIENCY BLOOD STASIS/TCD therapy
REINFORCING QI ACTIVAT BLOOD
@NAOSHUANKANG/ther.use
