摘要
目的：为探讨疱疹止痛灵治疗带状疱疹后遗神经痛的效果和镇痛作用机理。方法：对疱疹止痛灵进行了系统的临床观察和动物实验研究。结果：临床应用疱疹止痛灵治疗带状疱疹后遗神经痛３１５ 例，总有效率９６．５％ ，而对照组７９ 例，总有效率 ４４．３％ ，结果显示治疗组优于对照组（Ｐ＜ ０．０１）。结论：经临床及实验研究结果表明，疱疹止痛灵不仅能有效治疗带状疱疹后遗神经痛，而且实验证明，疱疹止痛灵镇痛作用对于外周交感神经末稍有阻断作用 止痛作用，而对侧脑室给予疱疹止痛灵无镇痛作用。从而证明该药止痛部位在外周交感神经末稍。
Objective:To explore the effect of herpetic neuralgia killer (HNK) on treatment of postherpetic neuralgia and its analgesic mechanism.Methods:Clinical observation and animal experimental study were on effect of herpetic neuralgia killer.Results:315 cases were treated with HNK and 79 cases in control group,and the total effective rate was 96.5% and 44.3% respectively.Conclusion:The treated group had a better curative effect than the control group.The effect of HNK on treatment of postherpetic neuralgia was affirmative,which demonstrated that HNK could block the afferent transduction of sympathetic terminals.The HNK injected cerebroventricularly ahd no effect on analgesia.The location of analgesia is in the afferent transduction of sympathetic terminals,not in nerve centre.
出处
《白求恩医科大学学报》
CSCD
1999年第6期721-724,共4页
Journal of Norman Bethune University of Medical Science
基金
吉林省中医管理局科研基金
关键词
带状疱疹
神经痛
疱疹止痛灵
中医药疗法
varicella zoster virus
herpes zoster
postherpetic neuralgia
herpetic neuralgia killer
analgesic study of the traditional Chinese medicine
