摘要
目的通过检测115例葡萄膜炎患者的人类白细胞抗原B27（HLA-B27）的表达,探讨葡萄膜炎患者HLA-B27的表达与性别、年龄的关系。方法采用流式细胞术对115例葡萄膜炎患者外周血进行HLA-B27抗原表达的检测,根据检测结果分为HLA-B27阳性组和阴性组,对数据进行统计分析。结果在62例男性葡萄膜炎患者中,46例HLA-B27阳性,而在53例女性患者中,27例HLA-B27阳性.男性患者阳性率（74.2%）大于女性患者（50.9%）。四格表χ^=6.66（P〈0.05）,男性组HLA-B27阳性的相对危险度为1.45,相对危险度的95%可信区间为0.98-1.92。男性葡萄膜患者和女性葡萄膜炎患者的年龄分布无明显差异（P〉0.05）,而不同性别的HLA-B27相关性葡萄膜炎患者的年龄分布有差异（P〈0.05）,男性患者年龄较女性患者小。结论男性是HLA-B27相关性葡萄炎发生的危险因素之一。
Objective To explore the correlation between HLA-B27 expression,gender and age in 115 patients with uveitis.Methods The expression of HLA-B27 in 115 cases of uveitis were analyzed by flow cytometry.According to the expression of HLA-B27,all the cases were divided into two groups（positive and negative）,and the result was analyzed statistically.Results In the 115 cases,46 males and 27 females were tested HLA-B27 positive with the positive rates of 74.2% and 50.9%.χ2 test suggested that there was significant difference between males and females in the expression of HLA-B27（χ^2=6.66,P〈0.05）.And male patients with uveitis suffered higher risk of the expression of HLA-B27 with the relative risk of 1.45 and 95% confidence interval（0.98-1.92）.while no significant difference was found between males and females in uveitis,males with HLA-B27 related uveitis were younger than females patients（P〈0.05）.Conclusion Male has the high risk infection of HLA-B27 related uveitis.
出处
《检验医学与临床》
CAS
2011年第16期1929-1930,共2页
Laboratory Medicine and Clinic
