摘要
目的分析非小细胞肺癌(NSCLC)患者血清VEGF、p53抗体表达水平及其诊断价值。方法采用酶联免疫吸附法(ELISA)检测69例初诊为NSCLC的患者血清VEGF和p53抗体浓度,另有45例健康志愿者作为对照。结果 NSCLC患者血清VEFG和p53抗体均明显高于对照组健康人群(P<0.001),两者在病理分型中腺癌最高(P<0.001),临床分期中以Ⅳ期最高(P<0.001);VEGF与p53抗体浓度值呈正相关(r=0.762,P<0.001);两项联合检测全部NSCLC的敏感性为86.9%,高于单项检测(P<0.001)。结论 NSCLC患者血清VEFG和p53抗体显著增高,检测患者血清这两项指标对于肺癌的临床辅助诊断有着重要意义。
Objective To explore the expression of serum VEGF and p53 antibody and their diagnoses value in non-small lung cancer（NSCLC）.Methods Serum levels of VEGF and p53 antibody were measured by enzyme-linked immunosorbent assay（ELISA） in 69 patients with NSCLC（as cancer group）,45 normal adults（as control group）.Results The serum levels of VEGF and p53 antibody in NSCLC were higher than them in control group（P0.001）.The highest values existed in adenocarcinoma of 4 pathological types,and in IV of clinical phases.Serum level of VEGF and p53 antibody were positive correlation（r=0.762,P0.001）.The susceptibility of the two indexes co-detection was 86.9%,higher than the single one（P0.001）.Conclusion The serum levels of VEGF and p53 antibody in NSCLC were remarkably increased in NSCLC,which were important indexes of lung cancer serodiagnoses.
出处
《实用心脑肺血管病杂志》
2011年第9期1469-1470,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
非小细胞肺癌
血管内皮生长因子
P53抗体
血清学诊断
None small cell lung cancer
Vascular endothelial growth factor
p53 antibody
Serodiagnosis
