摘要
目的:观察丙戊酸钠对妊娠小鼠的不良反应,探讨叶酸对其不良效应的干预效果。方法:将60只雌性和30只雄性小鼠随机分为3组(每组30只,雌雄比例2∶1),分别为:①对照组为灌胃蒸馏水10 ml/kg;②实验组为灌胃丙戊酸钠200 mg/kg;③干预组为灌胃丙戊酸钠200 mg/kg+叶酸0.07 mg/kg。观察小鼠的受孕率,妊娠小鼠的流产率、畸形率、死胎率,每窝仔鼠的数目及孕期增重情况等指标。结果:实验组小鼠的受孕率最低,对照组次之,干预组最高(P<0.05)。实验组妊娠小鼠的流产率、畸胎率和死胎率最高,对照组次之,干预组最低;而每窝正常仔鼠数目和孕期增重最少,对照组次之,干预组最多(P<0.05)。结论:丙戊酸钠可导致孕鼠的妊娠意外增多,补充叶酸可降低不良反应的风险。
Objective：To observe the adverse effect of sodium valproate on pregnant mice,explore the intervention effect of folic acid on the adverse effect.Methods：60 female mice and 30 male mice were randomly divided into 3 groups（30 mice in each group,female∶ male=2∶ 1）： the mice in control group were treated with pouring distilled water（10 ml/kg） into stomach;the mice in experimental group were treated with pouring sodium valproate（200 mg/kg） into stomach;the mice in intervention group were treated with pouring sodium valproate（200 mg/kg） and folic acid（0.07 mg/kg） into stomach.The indexes including pregnancy rate,abortion rate,aberration rate,stillbirth rate,the amount of neonatal mice in each brood and the body weight gain during pregnancy were observed.Results：The pregnancy rate of mice in experimental group was the lowest,followed by control group,the pregnancy rate of mice in intervention group was the highest（P〈0.05）.The abortion rate,aberration rate and stillbirth rate of mice in experimental group were the highest,followed by control group,the abortion rate,aberration rate and stillbirth rate of mice in intervention group were the lowest.The amount of neonatal mice in each brood and the body weight gain during pregnancy of mice in experimental group were the lowest,followed by control group,the amount of neonatal mice in each brood and the body weight gain during pregnancy of mice in intervention group were the highest（P〈0.05）.Conclusion：Sodium valproate can lead to increase of pregnant accident of pregnant mice,and supplement of folic acid can reduce the risk of adverse reactions.
出处
《中国妇幼保健》
CAS
北大核心
2011年第23期3624-3625,共2页
Maternal and Child Health Care of China
基金
唐山市计划指导项目〔09130202A-3-48〕
关键词
妊娠小鼠
丙戊酸钠
叶酸
不良反应
Pregnancy mouse
Sodium valproate
Folic acid
Adverse reaction
