摘要
目的探讨125I放射性粒子不同处方剂量近距离照射对家兔面神经超微结构的影响，旨为临床提供参考。方法将大耳白兔54只随机分为3个实验组：40Gy组、80Gy组、120Gy组，每组18只动物；每只动物自身对照，将125I粒子植入一侧腮腺区面神经周围，另一侧作为对照植入粒子空壳。每组分别于2、4、6个月时取面神经干做透射电镜观察。结果对照组：术后2、4、6个月均可见面神经轴膜连续、轴膜下轻度水肿，髓鞘局部松散。实验组：术后2个月均可见面神经轴膜下水肿、髓鞘松散，其中80Gy组可见巨噬细胞和新生神经纤维，120Gy组可见板层分离及新生神经纤维；4个月均可见面神经板层分离、髓鞘松散，其中40、80Gy组可见胶原增生及轴膜下水肿；6个月均可见新生神经纤维、髓鞘松散，其中80、120Gy组可见板层分离、轴膜下水肿。结论家兔面神经在接受40、80及120Gy 125I照射后，面神经超微结构存在一定的损伤，面神经受照射剂量越大损伤程度越重；但在120Gy 125I照射6个月后，髓鞘与轴突的完整性和连续性仍基本保持。
Objective To investigate the ultrastructural variation of the facial nerve of rabbit with different dosage of 125I seed brachytherapy. Methods Fifty-four big ear rabbits were divided into 3 groups randomly and given 40 Gy, 80 Gy, 120 Gy respectively. Radioactive seeds were implanted in one side of parotid gland, the other side was implanted with vacant shell as a control group. The facial nerves were obtained 2, 4, 6 months respectively after operation and the histological ultrastructural changes observed by electromicroscope. Results In the control group,epineurium was continuous, there was slight pitting edema under the epineurium, and axonal myelin was loose. In the test groups, there was slight pitting edema under the epineurium, and axonal myelin sheath was loose at 4th month. Macrophage and regenerated fibers were found in the 80 Gy group and myelin sheath lamellar separation, regeneration of nerve in the 120 Gy dosage. The myelin sheath lamellar was separated and axonal myelin loose in the test group at 6th month. Myelin sheath amellar separation and edema under the epineurium were found in the group of 80 Gy and 120 Gy. Conclusions The ultrastructure of the facial nerve is damaged by the dosage of 40 Gy, 80 Gy brachytherapy with 125I seeds. The higher dosage the nerve receives, the more serious the damage will be. Both of the epineurium and axonal myelin sheath are integral and continuous 6 months after operation with dosage of 120 Gy.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2011年第8期498-501,共4页
Chinese Journal of Stomatology
关键词
面神经
放射治疗剂量
放射性损伤
Facial nerve
Radiotherapy dosage
Radiation damage
