摘要
目的观察年轻恒牙去髓后牙髓组织的再生状态，研究牙髓组织的再生过程，为进一步探讨牙髓组织的再生机制提供依据。方法选取4只Beagle犬，每只犬8颗单根管上下颌切牙作为实验牙，拔除上下颌切牙牙髓并使血块充满髓腔，严密封闭开髓孔，分别于术后第7、14、21、28天处死动物，对牙齿及颌骨标本进行组织学观察。对照牙为2颗下颌切牙，未作任何处理。结果实验第7、14、21、28天实验牙根管内均富含细胞、血管分化良好的新生组织长人，并随观察时间的延长而增多，28d时新生组织基本长满髓腔。根尖部及根中部可见硬组织沉积，部分牙齿的根管内壁有钙化组织沉积，管壁增厚。对照牙根管内为正常牙髓组织。结论在保持根管无菌并严密封闭开髓孔的情况下，Beagle犬年轻去髓牙髓腔内可以再生分化良好的牙髓样组织。
Objective To observe the process of pulp revitalization of immature permanent teeth after pulpectomy. Methods Thirty-two single-rooted teeth with open apices from 4 Beagle dogs aged 4 months were included in the study. The pulpal tissues of 8 front teeth with single root of each dog were removed, and a blood clot was produced to the level of the cementoenamel junction followed by a double seal of mineral trioxide aggregate and composite resin. At day 7, 14, 21 and 28, respectively after operation, the dog was sacrificed, and then longitudinal paraffin sections were made for histologic investigation. Results After 7 days, about one thirth of the pulp chamber had an ingrowth of new tissue. After 14, 21, 28 days, there were more and more new tissue in the chamber. This new tissue consisted of well-organized and well- vascularized connective tissue. Hard tissue was too observed in the root canal. In some cases, the newly generated hard tissue even deposited against the canal dentinal walls. Conclusions The pulp of immature permanent teeth can revitalize after removal of the original pulp tissue under suitable conditions.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2011年第8期489-493,共5页
Chinese Journal of Stomatology
基金
基金项目：广东省科技计划（20078031302006）
关键词
动物
实验
牙髓
再生
新生血管化
生理性
Animals, laboratory
Dental pulp
Regeneration
Neovascularization,physiologic
