摘要
目的:探讨度洛西汀与艾司西酞普兰治疗抑郁症的疗效及安全性。方法:对66例抑郁症患者随机分为度洛西汀组(33例)和艾司西酞普兰组(33例),治疗剂量分别为40～60 mg/d和10～15 mg/d,观察6周。用汉密尔顿抑郁量表(HAMD17)评定疗效,用不良反应量表(TESS)评估不良反应和安全性。结果:治疗第1周末,度洛西汀组起效率为36.36%(12/33),艾司西酞普兰组为33.33%(11/33),两组间无显著性差异(P>0.05)。至第6周末度洛西汀组和艾司西酞普兰组的有效率分别为93.93%(31/33)、90.90%(30/33),两组间无显著性差异(P>0.05)。两组不良反应比较无显著性差异(P>0.05)。结论:度洛西汀和艾司西酞普兰对抑郁症患者同样安全有效。
Objective：To observe the efficacy and safety of Duloxetine and Escitalopram in the treatment of depression.Methods：Sixty-six patients with depression were randomly divided into Duloxetine group（n=33） and Escitalopram group（n=33）.The patients were treated with Duloxetine（40～60mg/d）or Escitalopram（10～15mg/d） for 6 weeks.The efficacy was assessed with Hamilton depression rating scale（HAMD17） and the side effects were assessed with treatment emergent symptoms scale（TESS）.Results： After the first week of treatment,the response rate was 36.36% in Duloxetine group and 33.33% in Escitalopram group without significant difference（P〉0.05）.After the 6-weeks treatment,the response rates in Duloxetine group and Escitalopram group were 93.93% and 90.90% respectively,without significant difference（P〉0.05）.There were no significant difference in side effect between these two groups.Conclusions： Duloxetine and Escitalopram are both effective and safe in the treatment of depression.
出处
《中国民康医学》
2011年第15期1860-1861,1893,共3页
Medical Journal of Chinese People’s Health
