摘要
目的研究酸枣仁总皂苷对行为绝望小鼠抑郁模型的影响。方法采用小鼠强迫游泳实验和悬尾实验抑郁模型,小鼠行为绝望的不动时间作为指标,考察酸枣仁总皂苷抗抑郁活性。结果酸枣仁总皂苷中、高剂量组均能减少小鼠强迫游泳和悬尾不动时间,与空白对照组比较差异有统计学意义(P<0.05,P<0.01)。结论酸枣仁总皂苷具有一定的抗抑郁作用。
Objective To observe the antidepressant effect of total saponins from Semen Ziziphi Spinosae in mice.Methods To investigate the antidepressant activity of total saponins from Semen Ziziphi Spinosae by the forced swimming test and tail suspension test,with the immobility time of behavioral despair mice as the indicator.Results Different dose groups of total saponins from Semen Ziziphi Spinosae significantly reduced the immobility time of the mice during the forced swimming test and the tail suspension test（P〈0.05,P〈0.01）.Conclusion The total saponins from Semen Ziziphi Spinosae have antidepressant effect.
出处
《中南药学》
CAS
2011年第7期489-491,共3页
Central South Pharmacy
基金
天津市高等学校发展项目基金(编号:20070305)
关键词
酸枣仁
总皂苷
抗抑郁
行为绝望
Semen Ziziphi Spinosae； total saponins； antidepressant effect； behavioral despair
