摘要
目的探索OPN、MMP-9在胰腺癌组织中的表达情况。方法采用免疫组织化学方法检测46例胰腺癌患者手术切除的正常胰腺组织和胰腺癌组织中的OPN、MMP-9的表达情况,并对不同肿瘤分化程度、临床分期及淋巴结转移的标本作对比分析。结果胰腺癌与正常组织之间OPN、MMP-9阳性表达率均有显著性差异(P<0.05),正常组织显著高于胰腺癌组织;胰腺癌与正常组织之间,两种大分子蛋白的表达与胰腺癌的组织分化程度、临床分期密切相关(P<0.05)。有淋巴结转移的OPN的表达与无淋巴结转移的有显著性差异(P<0.05)。结论 OPN、MMP-9两种大分子蛋白与胰腺癌的发生、发展密切相关。
【Objective】 explore expression of OPN,MMP-9 in pan-creatic cancer.【Methods】 Detected 46 cases who having pancreatic cancer resection of OPN,MMP-9 expression of normal pancreatic tissue and pancreatic cancer tissue by immunohistochemistry,and different degree of tumor differentiation,clinical stage and lymph node samples were analyzed.【Results】 Between pancreatic cancer and normal pancreatic tissue OPN,MMP-9 expression rates were significantly different（P 0.05）,pancreatic cancer tissue was significantly higher than the normal pancreatic tissue;between pancreatic cancer and normal tissue,Expression of two macromolecular protein Closely related with degree of differentiation pancreatic cancer cell and TNM stage（P 0.05）.Between Lymph node metastasis and on Lymph node metastasis OPN expression were significant difference（P 0.05）.【Conclusion】 OPN,MMP-9 are closely related with protein pancreatic cancer development.
出处
《中国医学工程》
2011年第6期60-61,64,共3页
China Medical Engineering
关键词
胰腺癌
基质金属蛋白酶-9
骨桥蛋白
pancreatic cancer
matrix metallo-proteinases-9
osteopontin
