摘要
目的:探讨中医早期介入的中西医结合综合方案治疗急性缺血性脑卒中的疗效。方法:采用随机、对照临床研究方法,将64例急性缺血性脑卒中患者随机分为试验组(n=32)和对照组(n=32),试验组采用中西医结合综合方案治疗,对照组采用西医综合方案治疗,观察两组患者在各时间点的NIHSS评分、Barthel指数(BI)及MRS评分等的变化。结果:①与入组时比较,试验组在治疗后7 d NIHSS评分就明显下降(P=0.011),而对照组直到治疗后14 d其NIHSS评分才出现显著降低(P=0.034)。组间比较显示,到治疗后21 d,试验组患者NIHSS评分的改善明显优于对照组(P<0.05)。②与入组时比较,试验组在治疗后7 d BI就显著提高(P=0.008),而对照组直到治疗后21 d其BI才显著提高(P=0.021)。组间比较显示,在治疗后14 d、21 d、3个月、6个月时,试验组患者BI的改善均优于对照组(均P<0.05)。③与入组时比较,两组患者日常生活不依赖(MRS评分≤3分)人数均于治疗后14 d显著增加(均P<0.05)。组间比较显示,在各时间点两组MRS评分≤3分者增加的例数比较均无显著差异(均P>0.05)。结论:中西医结合综合方案能更快、更好地改善急性缺血性脑卒中患者的神经功能缺损症状及日常生活活动能力,安全性好,无不良反应。
Objective： To explore the effects of the comprehensive protocol of integrated Chinese and western medicine with the early intervention of traditional Chinese medicine on acute ischemic stroke.Methods： Sixty-four patients with acute ischemic stroke were divided into test group（n=32） and control group（n=32） through the randomized and controlled clinical trial.The test group was treated by the comprehensive protocol of integrated Chinese and western medicine,and the control group was treated by comprehensive protocol of western medicine.The scores of national institutes of health stroke scale（NIHSS）,Barthel Index（BI） and the scores of Modified Rankin Scale（MRS） were observed at different time points.Results： ①Compared with before treatment,the scores of NIHSS in test group significantly decreased seven days after treatment（P=0.011）,while until fourteen days after treatment,the scores of NIHSS in control group significantly decreased（P=0.034）.Until twenty-one days after treatment,the improvement of the scores of NIHSS in test group was better than control group（P0.05）.②Compared with before treatment,the BI in test group obviously increased seven days after treatment（P=0.008）,while until twenty-one days after treatment,the BI in control group obviously increased（P=0.021）.Fourteen days,twenty-one days,three months and six months after treatment,the improvement of BI in test group was better than control group（P0.05）.③ Compared with before treatment,the number of patients who could rely on themselves in daily life（the scores of MRS≤3）obviously increased in both groups fourteen days after treatment（P0.05）.There was no statistical difference in the increasing cases of the scores of MRS≤3 between two groups at different time points（P0.05）.Conclusion： The comprehensive protocol of integrated Chinese and western medicine can improve the neurological impairment symptoms and the ability of daily life of patients with acute ischemic stroke faster and bett
出处
《上海中医药大学学报》
CAS
2011年第4期55-59,共5页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家"十一五"科技支撑计划资助项目(2006BAI04A02-3)
上海市卫生局中医药科研重大项目(2006ZD02)
国家中医药管理局中医药重点学科建设项目
关键词
急性缺血性脑卒中
中西医结合
综合疗法
随机对照试验
Acute ischemic stroke
integrated Chinese and western medicine
comprehensive protocol
randomized and controlled trial
